Loky do ★ Egypt, 2020-07-19 03:33 (1669 d 21:44 ago) Posting: # 21746 Views: 3,608 |
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Dears In partially replicate 3-way design, FDA recommends using the following example for sequence assignments 1,2,3 --> (TRR, RTR, RRT), if we used different sequence assignments 1,2,3 --> (TRR, RRT, RTR), is this change significant? or is it ok as long as it's considered in statistical analysis? Thanks in advance |
Helmut ★★★ ![]() ![]() Vienna, Austria, 2020-07-19 13:17 (1669 d 12:00 ago) @ Loky do Posting: # 21748 Views: 2,982 |
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No Loky do, it is not relevant how you code sequences and in which order. You could call them trousers.shirt.shirt , shirt.trousers.shirt , shirt.shirt.trousers as well. You have only to adapt the SAS-code at the end of the guidance’s page 4 accordingly.Why on earth do you want a partial replicate design? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![]() Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Loky do ★ Egypt, 2020-07-20 02:10 (1668 d 23:08 ago) @ Helmut Posting: # 21752 Views: 2,922 |
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❝ Why on earth do you want a partial replicate design? ![]() ![]() ![]() Thanks Helmut ![]() |
Helmut ★★★ ![]() ![]() Vienna, Austria, 2020-07-20 12:04 (1668 d 13:13 ago) @ Loky do Posting: # 21757 Views: 2,942 |
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Hi Loky do, ❝ I think some countries like ours are very traditional in following guidelines,… Agree. But the Egyptian GL of 2017 in Section 3.2 recommends the EMA’s approach and not the FDA’s. That’s not a different league but a different sport. For the SAS-codes recommended by the EMA see the Q&A document. Alternatively* you can use Phoenix/WinNonlin, STATISTICA, SPSS, Stata, JPM, or the replicateBE .❝ why using partially replicate design is not favorable nowadays? As a starter see this post and that one. I suggest also to search the forum with the keywords lousy and design. Most important reasons:
— Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![]() Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Loky do ★ Egypt, 2020-07-22 12:17 (1666 d 13:00 ago) @ Helmut Posting: # 21772 Views: 2,817 |
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Thanks a lot, Helmut ![]() |