ksreekanth
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India,
2020-05-20 15:22
(1515 d 12:25 ago)

Posting: # 21453
Views: 2,193
 

 Processed Sample Stability [Bioanalytics]

Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.
Any further PS Stability experiment need to be proved at refrigerator (4°C) condition. Since auto-sampler condition were maintained at 10°C during the Processed Sample analysis.


Edit: Category changed; see also this post #1; please follow the Forum’s Policy[Helmut]
Helmut
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Vienna, Austria,
2020-05-20 18:29
(1515 d 09:19 ago)

@ ksreekanth
Posting: # 21454
Views: 1,691
 

 Processed Sample Stability

Hi ksreekanth,

❝ Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.


What are your thoughts – do you remember the Arrhenius equation? However, in the strict sense (!) autosampler stability  processed sample stability.

This reminds me on heated discussions at the Crystal City III workshop along these lines:

“We have validated long-term stability at –20℃.
Can we store samples at –70℃ without re-validation?”

Amazingly some answered “No!”
Was – and is – beyond my intellectual reach. See also Ohlbe’s post.

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