ksreekanth
☆    

India,
2020-05-20 15:22
(1493 d 10:01 ago)

Posting: # 21453
Views: 2,124
 

 Processed Sample Stability [Bioanalytics]

Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.
Any further PS Stability experiment need to be proved at refrigerator (4°C) condition. Since auto-sampler condition were maintained at 10°C during the Processed Sample analysis.


Edit: Category changed; see also this post #1; please follow the Forum’s Policy[Helmut]
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2020-05-20 18:29
(1493 d 06:54 ago)

@ ksreekanth
Posting: # 21454
Views: 1,643
 

 Processed Sample Stability

Hi ksreekanth,

❝ Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.


What are your thoughts – do you remember the Arrhenius equation? However, in the strict sense (!) autosampler stability  processed sample stability.

This reminds me on heated discussions at the Crystal City III workshop along these lines:

“We have validated long-term stability at –20℃.
Can we store samples at –70℃ without re-validation?”

Amazingly some answered “No!”
Was – and is – beyond my intellectual reach. See also Ohlbe’s post.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
UA Flag
Activity
 Admin contact
23,059 posts in 4,841 threads, 1,663 registered users;
31 visitors (0 registered, 31 guests [including 6 identified bots]).
Forum time: 01:24 CEST (Europe/Vienna)

[…] an inappropriate study design is incapable of answering
a research question, no matter how careful the subsequent
methodology, conduct, analysis, and interpretation:
Flawless execution of a flawed design achieves nothing worthwhile.    J. Rick Turner

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5