jag009
★★★

NJ,
2020-04-14 23:33
(1550 d 17:37 ago)

Posting: # 21330
Views: 4,249
 

 Variability in PK from IM injection [PK / PD]

Hi everyone,

I once heard that IM injection tends to yield higher variability in PK, is that true? Relative to IV.

Thanks
John
ElMaestro
★★★

Denmark,
2020-04-15 00:02
(1550 d 17:08 ago)

@ jag009
Posting: # 21331
Views: 2,312
 

 Variability in PK from IM injection

Hi John,

❝ I once heard that IM injection tends to yield higher variability in PK, is that true? Relative to IV.


I think that's true by some margin, usually.
One joker is that IM is not IM. Quite a few IM injections end up being SC in part or in whole.

Pass or fail!
ElMaestro
Helmut
★★★
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Vienna, Austria,
2020-04-15 00:56
(1550 d 16:14 ago)

@ jag009
Posting: # 21332
Views: 2,310
 

 Variability EV > IV (always)

Hi John,

❝ […] IM injection tends to yield higher variability in PK, is that true? Relative to IV.


By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).

Sorry for the long sentence.

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jag009
★★★

NJ,
2020-04-21 23:00
(1543 d 18:10 ago)

@ Helmut
Posting: # 21340
Views: 2,187
 

 Variability EV > IV (always)

Thank you both :)
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