Aisha.ma ☆ United Arab Emirates, 2019-10-07 07:46 (1041 d 19:48 ago) Posting: # 20672 Views: 3,676 |
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Dear all, I am a biostatistician, and I have a project about insulin glargine. The parameter t50%GIR-AUC(0-8h) will be analysed, but I don't know how to get this parameter. Can I get it by WinNolin software and which parameter in WinNonlin will be? ![]() Edit: Category changed; see also this post #1. [Helmut] |
Helmut ★★★ ![]() ![]() Vienna, Austria, 2019-10-07 09:52 (1041 d 17:42 ago) @ Aisha.ma Posting: # 20673 Views: 3,117 |
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Salam Aisha, t50% (aka HVD – Half Value Duration, POT-50 – Peak Occupancy Time 50%) is not one of the PK metrics implemented in Phoenix WinNonlin.
— Dif-tor heh smusma 🖖 ![]() Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Aisha.ma ☆ United Arab Emirates, 2019-10-07 16:12 (1041 d 11:21 ago) @ Helmut Posting: # 20675 Views: 3,102 |
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W.salam Helmut, Thank you very much. Now I know how to get t50% Cmax via Phoenix WinNonlin. But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours). So next what should I do if I know HVD? I hope you help me again. ![]() |
Helmut ★★★ ![]() ![]() Vienna, Austria, 2019-10-07 16:58 (1041 d 10:36 ago) @ Aisha.ma Posting: # 20676 Views: 3,132 |
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Hi Ashima, BTW, are you referring to this guideline? » But I want to know t50% AUC(0-8h) (time to 50% of AUC, and my last sample was scheduled at 8 hours). Just to clarify: Are you interested in the yellow area? Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out. Or this one? » So next what should I do if I know HVD? Both are not easy to calculate because HVD is the difference between the two intersections times which you don’t get in Phoenix. I suggest to register at Certara’s forum and post an example project containing the data of one subject. Ideas:
— Dif-tor heh smusma 🖖 ![]() Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Aisha.ma ☆ United Arab Emirates, 2019-10-07 18:43 (1041 d 08:50 ago) @ Helmut Posting: # 20677 Views: 3,054 |
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Hi Helmut, » BTW, are you referring to this guideline? Maybe the sponsor had consult this guideline before designing the study . Gir is the glucose-infusion rate. » Just to clarify: Are you interested in the yellow area? » » Doesn’t look like your GIR cause that’s a PK profile but you get the idea. IIRC, this was called AUCapical by the “Two Lászlós” (Endrényi and Tóthfalusi). Have to dig it out. I need to know time to 50% of GIR-AUC0-8. At the begining, I think that I can use summary table from Phoenix resluts and the function of AUC to get this time, but I am not sure whether this idea is right. I have search many meterials about glucose-infsion study, this parameter is the secondary end. So it is a common parameter in glucose-infsion study, but I can not find the calculating mathod. ![]() |
Helmut ★★★ ![]() ![]() Vienna, Austria, 2019-10-07 18:54 (1041 d 08:40 ago) @ Aisha.ma Posting: # 20678 Views: 3,089 |
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Hi Aisha, » I need to know time to 50% of GIR-AUC0-8. That’s not my field. If the sponsor is so clever to demand a certain metric, ask what is exactly meant. » At the begining, I think that I can use summary table from Phoenix resluts and the function of AUC to get this time, but I am not sure whether this idea is right. No, this will not work. » So it is a common parameter in glucose-infsion study, but I can not find the calculating mathod. Fantastic. Keep searching. Once you know how it is defined, we can try to come up with a calculation method. Not before. Sorry. — Dif-tor heh smusma 🖖 ![]() Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Aisha.ma ☆ United Arab Emirates, 2019-10-07 19:02 (1041 d 08:31 ago) @ Helmut Posting: # 20679 Views: 3,053 |
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Hi Helmut, Thank you so much. You have give me many useful information. I will search continue and I hope other experts in this forum also can help me. |
nobody nothing 2019-10-08 10:51 (1040 d 16:43 ago) @ Aisha.ma Posting: # 20681 Views: 3,008 |
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— Kindest regards, nobody |