jag009
★★★

NJ,
2019-08-22 12:53
(350 d 05:48 ago)

Posting: # 20506
Views: 1,728
 

 Intrasubject CV for fed studies [PK / PD]

Hi,
Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)?

Thanks
J
ElMaestro
★★★

Belgium?,
2019-08-22 19:56
(349 d 22:46 ago)

@ jag009
Posting: # 20507
Views: 1,473
 

 Intrasubject CV for fed studies

Hi jag,

» Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)?

It is not readily possible. Both a negative and a positive food effect can be accompanied by a decreased or increased CV. You'll need to work hard for this one :crying:

I could be wrong, but...

Best regards,
ElMaestro

"Pass or fail" (D. Potvin et al., 2008)
zaibo liu
☆    

China,
2019-08-23 00:54
(349 d 17:48 ago)

@ jag009
Posting: # 20508
Views: 1,459
 

 Intrasubject CV for fed studies

» Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)?

It is not possible, but intrasubject CV is always small than fasting for BCS II or first pass drug.
jag009
★★★

NJ,
2019-09-04 04:32
(337 d 14:10 ago)

@ zaibo liu
Posting: # 20538
Views: 1,310
 

 Intrasubject CV for fed studies

Thanks guys,

» It is not possible, but intrasubject CV is always small than fasting for BCS II or first pass drug.

You mean ISCV is smaller under fed (than fasting) for BCS II? Any example drug?

Thanks
John
Activity
 Admin contact
20,969 posts in 4,374 threads, 1,460 registered users;
online 13 (0 registered, 13 guests [including 11 identified bots]).
Forum time: Thursday 18:42 UTC (Europe/Vienna)

It is a good morning exercise for a research scientist
to discard a pet hypothesis every day before breakfast.
It keeps him young.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5