(1706 d 06:50 ago)
Posting: # 19827
How to calculate sample size for pivotal ophthalmic PK endpoint study (having Only one single sample of aqueous humor is collected from one eye of each patient) which bootstrapping techniques are utilized for final BE conclusion...???
(1704 d 19:28 ago)
Posting: # 19836
if you don't have analytical solution - look for simulations approach
Simulate the data using known distribution parameters, desired sample size and then use bootstrap technique for evaluation. Repeat it ad-hoc (until the success/failure ratio stabilizes). Then change the sample size and repeat until desired power is reached. Don't forget about SciAdv.