(1708 d 08:37 ago)
Posting: # 19809
I just have quick questions for you all - quite basic.
(1707 d 04:22 ago)
(edited by mittyri on 2019-01-27 09:52)
Posting: # 19810
❝ When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred?
❝ When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment?
In WNL wordings
MRTlast = AUMClast/AUClast (bolus case)
If the coverage of PK profile is enough, the estimation of MRT would be fair enough too.
❝ What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k?
❝ When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different?
Thus since HL = ln(2)/kel
the distribution of parameters won't be the same.
Simple example in R
(1705 d 08:10 ago)
Posting: # 19818