PKBR ☆ Brazil, 2019-01-25 19:27 (1708 d 08:37 ago) Posting: # 19809 Views: 3,029 |
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Dear all, I just have quick questions for you all - quite basic.
Many thanks, PKBR. - |
mittyri ★★ Russia, 2019-01-26 23:42 (1707 d 04:22 ago) (edited by mittyri on 2019-01-27 09:52) @ PKBR Posting: # 19810 Views: 2,632 |
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Dear PKBR, ❝ When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred? ❝ When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment? In WNL wordings MRTlast = AUMClast/AUClast (bolus case) If the coverage of PK profile is enough, the estimation of MRT would be fair enough too. ❝ What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k? ❝ When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different? Thus since HL = ln(2)/kel the distribution of parameters won't be the same. Simple example in R > t.test(1:10, y = c(7:20)) — Kind regards, Mittyri |
PKBR ☆ Brazil, 2019-01-28 19:54 (1705 d 08:10 ago) @ mittyri Posting: # 19818 Views: 2,507 |
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Thanks! |