PKBR ☆ Brazil, 20190125 18:27 Posting: # 19809 Views: 462 

Dear all, I just have quick questions for you all  quite basic.
Many thanks, PKBR.  
mittyri ★★ Russia, 20190126 22:42 (edited by mittyri on 20190127 09:52) @ PKBR Posting: # 19810 Views: 382 

Dear PKBR, » When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred? No one else but Helmut answered that question here » When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment? MRT is derived from AUC and AUMC. In WNL wordings MRTlast = AUMClast/AUClast (bolus case) If the coverage of PK profile is enough, the estimation of MRT would be fair enough too. » What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k? look at the partial AUC calculation rules in WNL guide cited here. I think it is what are you looking for. » When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different? The result of statistical test depends on the assumption of distribution of parameter. Thus since HL = ln(2)/kel the distribution of parameters won't be the same. Simple example in R > t.test(1:10, y = c(7:20)) — Kind regards, Mittyri 
PKBR ☆ Brazil, 20190128 18:54 @ mittyri Posting: # 19818 Views: 298 

Thanks! 