BE-proff ★★ Russia, 2018-12-24 16:58 (762 d 04:29 ago) Posting: # 19714 Views: 1,987 |
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Hi All, ![]() let's say I want to conduct a BE study using RSABE (EMA). From previous studies I have both AUCs and Cmax with their GMR and CVintra. Which parameter is better for sample size calculation - AUC or Cmax? |
mittyri ★★ Russia, 2018-12-24 20:33 (762 d 00:54 ago) @ BE-proff Posting: # 19715 Views: 1,616 |
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Hi BE-proff, » From previous studies I have both AUCs and Cmax with their GMR and CVintra. » Which parameter is better for sample size calculation - AUC or Cmax? You need to take into account both. Remember this one? ![]() The leading metric depends on CV and GMR. — Kind regards, Mittyri |