ramgopi
☆    

India,
2018-12-03 13:30

Posting: # 19666
Views: 585
 

 Solubility Testing-Shake flask method [Dissolution / BCS / IVIVC]

Dear All

could you please any one clarify the formula to calculate the quantity of drug substance dissolved in each buffer for solubility test using shake flask method, does we have to consider sample concentration/weight for the calculation? hope the solubility of the drug doesn't going to change even addition of extra amount of drug after attaining the equilibrium.

I hope this would be a very old topic and enormous data available in web but i couldn't get the exact formula.:-D:-D

Thanks & Regards
Gopinath


Edit: category changed [Ohlbe]
Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
19,537 posts in 4,144 threads, 1,338 registered users;
online 8 (0 registered, 8 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 17:30 CEST

When puzzled, it never hurts to read the primary documents –
a rather simple and self-evident principle that has, nonetheless,
completely disappeared from large sectors
of the American experience.    Stephen Jay Gould

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5