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heritage
Junior

India,
2018-11-24 15:36

Posting: # 19649
Views: 200
 

 Dextromethorphan 90 mg in a single dose [Design Issues]

Dear All

I am looking for help in deciding whether it is safe to administer Dextromethorphan sustained release 90 mg syrup in a single dose in healthy adults and study its pharmacokinetic profile?

According to dosage guide of Delsym, for adults it is 10 mL (60 mg) every 12 hours and should not exceed 20 mL (120 mg) in 24 hours. I could get one study wherein 60 mg was given in health volunteers (https://europepmc.org/abstract/med/3679620. I could not get specific study wherein 90 mg was administered as a single dose in healthy volunteers.
Ohlbe
Hero

France,
2018-11-26 10:33

@ heritage
Posting: # 19651
Views: 152
 

 Dextromethorphan 90 mg in a single dose

Dear Heritage,

» According to dosage guide of Delsym, for adults it is 10 mL (60 mg) every 12 hours and should not exceed 20 mL (120 mg) in 24 hours.

Is there any particular reason why you want to give a single dose of 90 mg rather than 60 mg, then ?

Regards
Ohlbe
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