heritage
☆    

India,
2018-11-24 15:36

Posting: # 19649
Views: 676
 

 Dextromethorphan 90 mg in a single dose [Design Issues]

Dear All

I am looking for help in deciding whether it is safe to administer Dextromethorphan sustained release 90 mg syrup in a single dose in healthy adults and study its pharmacokinetic profile?

According to dosage guide of Delsym, for adults it is 10 mL (60 mg) every 12 hours and should not exceed 20 mL (120 mg) in 24 hours. I could get one study wherein 60 mg was given in health volunteers (https://europepmc.org/abstract/med/3679620. I could not get specific study wherein 90 mg was administered as a single dose in healthy volunteers.
Ohlbe
★★★

France,
2018-11-26 10:33

@ heritage
Posting: # 19651
Views: 551
 

 Dextromethorphan 90 mg in a single dose

Dear Heritage,

» According to dosage guide of Delsym, for adults it is 10 mL (60 mg) every 12 hours and should not exceed 20 mL (120 mg) in 24 hours.

Is there any particular reason why you want to give a single dose of 90 mg rather than 60 mg, then ?

Regards
Ohlbe
Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
19,400 posts in 4,121 threads, 1,323 registered users;
online 10 (0 registered, 10 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 18:20 CEST

Science is the great antidote to the poison
of enthusiasm and superstition.    Adam Smith

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5