(1914 d 17:47 ago)
Posting: # 19249
Is it possible to design the reference scaled approach following parallel study (single period)?
If yes, how to design the study, randomization and statistical procedures?
(1914 d 16:37 ago)
Posting: # 19250
❝ Is it possible to design the reference scaled approach following parallel study (single period)?
By definition reference-scaling is applicable if the within-subject variability of the reference is >30%. CVwR is not accessible in a parallel design (not even CVw…).
❝ If yes, how to design the study, randomization and statistical procedures?
Tóthfalusi and Endrényi proposed a method for studies in a parallel design.1 However, in a follow-up paper2 they didn’t mention parallel designs any more. Given the troubles we already are facing with replicate designs (inflation of the Type I Error, convergence issues in the partial replicate) I guess the chance of a rather exotic approach to be accepted by any agency is practically zero.
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
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(1913 d 14:59 ago)
Posting: # 19252
Thank You! HS