Deepti Maru

2018-04-07 19:48
(2001 d 09:44 ago)

Posting: # 18653
Views: 2,358

 Selection of linearity range in bioanalysis [Bioanalytics]

What is the need to go down upto 5 or 7 or 10 half lives while developing a bioanalytical method?

Edit: Please follow the Forum’s Policy[Helmut]

2018-05-03 12:35
(1975 d 16:57 ago)

@ Deepti Maru
Posting: # 18752
Views: 1,626

 Selection of linearity range in bioanalysis

Dear Deepti Maru,

The need to have lower LOQ (5,7 or 10 half lives) should be correlated to the number of half lives upto which sample is collected as per protocol or likely to be collected

If the sampling is carried out upto 6 half lives - For a drug with 12 Hr Half life, the last sampling point will be 72 hours. Under such scenario, LOQ can be upto 7 half lives

This will ensure possibility of minimal BLQ samples in absorption / elimination phase.

It is necessary to have a reproducible LOQ

UA Flag
 Admin contact
22,763 posts in 4,775 threads, 1,627 registered users;
17 visitors (0 registered, 17 guests [including 11 identified bots]).
Forum time: 05:32 CEST (Europe/Vienna)

We should not speak so that it is possible
for the audience to understand us,
but so that it is impossible
for them to misunderstand us.    Quintilian

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz