youivab
☆    

Korea,
2017-12-27 07:20
(2703 d 16:16 ago)

(edited on 2017-12-28 01:38)
Posting: # 18089
Views: 6,798
 

 IntraCV calculation [Power / Sample Size]

Dear All,

I have a question.

<Pre-study, 1*2, Crossover design.>

When calculating Intra CV, is there a case of 0?
What should I do in such case?


Edit: Category changed; see also this post #1. [Helmut]
BE-proff
●    

2017-12-27 07:49
(2703 d 15:47 ago)

@ youivab
Posting: # 18090
Views: 5,795
 

 IntraCV calculation

Hi youivab,

Unclear question.
Are you talking about already done study?
youivab
☆    

Korea,
2017-12-28 02:35
(2702 d 21:01 ago)

@ BE-proff
Posting: # 18105
Views: 5,684
 

 IntraCV calculation

❝ Unclear question.

❝ Are you talking about already done study?


yes, already done and calculated AUClast, Cmax ...
kms.srinivas
☆    

India,
2017-12-27 07:53
(2703 d 15:43 ago)

@ youivab
Posting: # 18092
Views: 5,763
 

 IntraCV calculation

❝ When calculating Intra CV, is there a case of 0?

❝ What should I do in such case?


intra CV zero!!!
Are you dealing with man or machine?!! :confused: which have also a little precision...
youivab
☆    

Korea,
2017-12-28 02:37
(2702 d 20:59 ago)

@ kms.srinivas
Posting: # 18106
Views: 5,580
 

 IntraCV calculation

❝ intra CV zero!!!

❝ Are you dealing with man or machine?!! :confused: which have also a little precision...


I used SAS program.

This is the code I used.

ODS OUTPUT COVPARMS=RESIDUAL8;
PROC MIXED DATA=FED_VDCL;
  CLASS SUB P;
  MODEL LVD= P;
  RANDOM SUB;
  REPEATED/GRP=SUB SUB=SUB;
  LSMEANS /PDIFF CL ALPHA=0.1;
RUN;
DATA RESIDUAL8;
  SET RESIDUAL8;
  IF COVPARM NE 'Residual' THEN DELETE;
  INTRACV=SQRT(EXP(ESTIMATE)-1)*100;
RUN;



Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer. Tabulators changed to spaces and BBcoded; see also this post #5 and #6. [Helmut]
GM
★    

India,
2017-12-28 07:56
(2702 d 15:40 ago)

@ youivab
Posting: # 18109
Views: 5,461
 

 IntraCV calculation

❝ This is the code I used.


ODS OUTPUT COVPARMS=RESIDUAL8;

❝ PROC MIXED DATA=FED_VDCL;

❝   CLASS SUB P;
❝   MODEL LVD= P;
❝   RANDOM SUB;
❝   REPEATED/GRP=SUB SUB=SUB;
❝   LSMEANS /PDIFF CL ALPHA=0.1;

❝ RUN;

❝ DATA RESIDUAL8;

❝   SET RESIDUAL8;
❝   IF COVPARM NE 'Residual' THEN DELETE;
❝   INTRACV=SQRT(EXP(ESTIMATE)-1)*100;

❝ RUN;


Hi Youivab,

My understanding as per this code, this is Parallel Design.

I think, because of random effect in the model, the inter CV is zero.

Regards,
GM

Best Regards,
GM
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