youivab
☆

Korea,
2017-12-27 07:20
(2423 d 05:35 ago)

(edited by youivab on 2017-12-28 01:38)
Posting: # 18089
Views: 6,094

## IntraCV calculation [Power / Sample Size]

Dear All,

I have a question.

<Pre-study, 1*2, Crossover design.>

When calculating Intra CV, is there a case of 0?
What should I do in such case?

BE-proff
●

2017-12-27 07:49
(2423 d 05:06 ago)

@ youivab
Posting: # 18090
Views: 5,225

## IntraCV calculation

Hi youivab,

Unclear question.
youivab
☆

Korea,
2017-12-28 02:35
(2422 d 10:20 ago)

@ BE-proff
Posting: # 18105
Views: 5,124

## IntraCV calculation

❝ Unclear question.

yes, already done and calculated AUClast, Cmax ...
kms.srinivas
☆

India,
2017-12-27 07:53
(2423 d 05:01 ago)

@ youivab
Posting: # 18092
Views: 5,208

## IntraCV calculation

❝ When calculating Intra CV, is there a case of 0?

❝ What should I do in such case?

intra CV zero!!!
Are you dealing with man or machine?!! which have also a little precision...
youivab
☆

Korea,
2017-12-28 02:37
(2422 d 10:17 ago)

@ kms.srinivas
Posting: # 18106
Views: 5,015

## IntraCV calculation

❝ intra CV zero!!!

❝ Are you dealing with man or machine?!! which have also a little precision...

I used SAS program.

This is the code I used.

ODS OUTPUT COVPARMS=RESIDUAL8; PROC MIXED DATA=FED_VDCL;   CLASS SUB P;   MODEL LVD= P;   RANDOM SUB;   REPEATED/GRP=SUB SUB=SUB;   LSMEANS /PDIFF CL ALPHA=0.1; RUN; DATA RESIDUAL8;   SET RESIDUAL8;   IF COVPARM NE 'Residual' THEN DELETE;   INTRACV=SQRT(EXP(ESTIMATE)-1)*100; RUN;

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer. Tabulators changed to spaces and BBcoded; see also this post #5 and #6. [Helmut]
GM
★

India,
2017-12-28 07:56
(2422 d 04:58 ago)

@ youivab
Posting: # 18109
Views: 4,918

## IntraCV calculation

❝ This is the code I used.

ODS OUTPUT COVPARMS=RESIDUAL8;

❝ PROC MIXED DATA=FED_VDCL;

 ❝   CLASS SUB P; ❝   MODEL LVD= P; ❝   RANDOM SUB; ❝   REPEATED/GRP=SUB SUB=SUB; ❝   LSMEANS /PDIFF CL ALPHA=0.1;❝ RUN; ❝ DATA RESIDUAL8; ❝   SET RESIDUAL8; ❝   IF COVPARM NE 'Residual' THEN DELETE; ❝   INTRACV=SQRT(EXP(ESTIMATE)-1)*100;

❝ RUN;

Hi Youivab,

My understanding as per this code, this is Parallel Design.

I think, because of random effect in the model, the inter CV is zero.

Regards,
GM

Best Regards,
GM