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priyanka ☆ 2008-04-29 11:34 (6636 d 23:16 ago) Posting: # 1800 Views: 10,831 |
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Dear all, I want to know why we take median of Tmax instead of mean in PK analysis. please give the guidance about it. Thanks in advance, Priyanka Bhavsar -- Edit: Category changed. [Helmut] |
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Helmut ★★★   Vienna, Austria, 2008-04-29 14:51 (6636 d 19:59 ago) @ priyanka Posting: # 1802 Views: 9,186 |
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Dear Priyanka! ❝ I want to know why we take median of Tmax … Tmax is strongly dependent on the chosen sampling scheme. The sampling distribution of Tmax will always be a discrete one (see here). ❝ … instead of mean in PK analysis. The (arithmetic) mean is the best unbiased estimator of the location of the normal distribution – but it can be substantially sub-optimal for distributions close to the normal and will be inferior for all discrete distributions. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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priyanka ☆ 2008-04-29 16:18 (6636 d 18:32 ago) @ Helmut Posting: # 1803 Views: 8,739 |
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Ing. Helmut Schütz