Posting: # 17829
Atorvastatin Calcium is known as highly variable drug but when we conducted a BE study on it, the results gave low intra-subject Variability (18%) and that's inconsistent with the usual results.
What could be the reason/s for this?
Edit: Category changed; see also this post #1. [Helmut]
Posting: # 17830
Lesser within-batch variability (-ies) than in the studies you compare to?
I could be wrong, but...
Posting: # 17832
» Better assay?
» Design differences?
» Lesser within-batch variability (-ies) than in the studies you compare to?
Variability has been attributed to various physiological sources, including e.g. liver function, transporter status:
Kindest regards, nobody
Posting: # 17833
Hi ElMaestro & nobody,
» » Chance?
» Maybe, but...
Quick calculations based on published CV (~35%), full replicate designs (n 40–64): Very, very unlikely; p <10–16.
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