mahmoud-teaima Regular 2017-06-08 17:45 Posting: # 17468 Views: 8,974 |
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Hello all, Can any of our R-coding experts advise me with an R code to do data analysis of partial replicate design "2x3x3" BE study according to FDA and EMA guidelines. Greetings. — Mahmoud Teaima, PhD. |
Helmut Hero ![]() ![]() Vienna, Austria, 2017-06-10 01:44 @ mahmoud-teaima Posting: # 17480 Views: 8,376 |
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Hi Mahmoud, » […] an R code to do data analysis of partial replicate design "2x3x3" BE study according to FDA and EMA guidelines. Good news: The EMA’s ‘Method A’ and ‘Method B’ are fairly easy to implement in R. I have code covering the following designs: RTRT|TRTR, RTTR|TRRT, RTR|TRT, RTT|TRR, RRT|RTR|TRR. The code handles balanced/unbalanced sequences and complete/incomplete data (i.e., periods missing). Example output:
I will send you the code by PM. Bad news: Evaluation of replicate designs which will give exactly the same results as SAS’ PROC MIXED according to the FDA’s progesterone guidance is not (and likely will never be) possible in R. Too different philosophies.Edit: Updated the output according to v0.95 of the R-code. — Cheers, Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes |
mahmoud-teaima Regular 2017-06-10 22:48 @ Helmut Posting: # 17484 Views: 8,011 |
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Salam Alikum Hilmut, Thanks for the code! Waiting you send it to me through email. Greetings. — Mahmoud Teaima, PhD. |
Helmut Hero ![]() ![]() Vienna, Austria, 2017-06-11 01:24 @ mahmoud-teaima Posting: # 17485 Views: 8,063 |
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Salam Mahmoud, » Waiting you send it to me through email. I’ve sent it already yesterday afternoon to the e-mail address you used in registering to the forum. Please check your inbox. I just sent it again to the three other addresses I found at your faculty’s website. This e-mail contains more explanations. Since you are working on MacOS I adapted the output: The file is encoded in UTF-8 with line endings CR (ASCII 13). Please report back whether it works (I don’t have a Mac to test it). — Cheers, Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes |
mahmoud-teaima Regular 2017-06-11 03:01 @ Helmut Posting: # 17486 Views: 8,043 |
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Salam Helmut, » I’ve sent it already yesterday afternoon to the e-mail address you used in registering to the forum. Please check your inbox. » I just sent it again to the three other addresses I found at your faculty’s website. This e-mail contains more explanations. Since you are working on MacOS I adapted the output: The file is encoded in UTF-8 with line endings CR (ASCII 13). I got the mail, thanks. » Please report back whether it works (I don’t have a Mac to test it). Sure, will check it and report back to you. Many thanks. Greetings to all participants in this effort. — Mahmoud Teaima, PhD. |
Yura Regular Belarus, 2017-09-04 21:22 @ Helmut Posting: # 17773 Views: 7,194 |
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Dear Helmut I use combined R and SAS (I use the EMA approach) to calculate the replicative design Is it possible to get from you the implementation code in R of the above described constructions? thank you very much for any answer Best regards! |
Helmut Hero ![]() ![]() Vienna, Austria, 2017-09-05 01:55 @ Yura Posting: # 17774 Views: 7,159 |
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Hi Yura, » Is it possible to get from you the implementation code in R of the above described constructions? It’s on GitHub: https://github.com/Helmut01/replicateBE Installation analogous to PowerTOST. See Detlew’s post. — Cheers, Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes |
Yura Regular Belarus, 2017-09-05 22:21 @ Helmut Posting: # 17783 Views: 7,125 |
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Thank you it remains only to run |
Helmut Hero ![]() ![]() Vienna, Austria, 2017-09-06 14:24 @ Yura Posting: # 17785 Views: 7,128 |
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Hi Yura, » it remains only to run If you have questions, please post here. If you think that you discovered a bug, keep it. ![]() No, seriously: Navigate to https://github.com/Helmut01/replicateBE/issues and click on New issue. — Cheers, Helmut Schütz ![]() The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes |
Yura Regular Belarus, 2017-09-08 08:54 @ Helmut Posting: # 17794 Views: 7,005 |
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