Pandu
★    

India,
2008-03-28 05:55
(6292 d 16:13 ago)

Posting: # 1728
Views: 7,562
 

 Fieller's Theorem [General Sta­tis­tics]

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Dear All,

Let me know the what is Fieller's Theorem and why it was used in BA/BE studies. At what reason we can apply this theorem. Also give me the details of this and study meterial also.

Thanks in advance,

Reagrd,
Pandu
 
Helmut
★★★
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Vienna, Austria,
2008-05-26 16:48
(6233 d 06:20 ago)

@ Pandu
Posting: # 1870
Views: 6,567
 

 Fieller's Theorem

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Dear Pandu,

Dieter Hauschke sent me a personal e-mail, which I quote below:

This theorem is used for calculation of confidence intervals for a ratio of expected means while assuming a normal distribution.

For concentration-related characteristics, a lognormal distribution is assumed in BA/BE studies. Hence, there is no need to apply Fieller's Theorem.

Please note that the application of this theorem in clinical trials is fully described in:
Hauschke D, Steinijans VW, Pigeot I
Bioequivalence: Methods and Applications, Statistics in Practice
John Wiley, Chichester (2007)

Kind regards
Dieter

--
Prof. Dr. Dieter Hauschke
Institute of Medical Biometry
and Medical Informatics
University Medical Center Freiburg
Stefan-Meier-Str. 26
D-79104 Freiburg
phone: +49 (0)761 203 6665
fax: +49 (0)761 203 6680
http://www.imbi.uni-freiburg.de


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