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velupharm ☆ 2006-07-14 07:43 (6874 d 08:58 ago) Posting: # 171 Views: 14,330 |
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Is there a way/method by which we can find the extent of absorption of a particular drug from different parts of GI tract, like for Ex 20% from stomach, 60% from duodenum etc. henderson-haselbach equation may give a idea based on the ionized-unionized status. but that may not be applicable in all cases (like penicillin, even though more than 99% is unionized in somach, real absorption takes place in intestine). my question may look little theoritical, but still if some one has any idea about it? I want to know if this can be done before a generic formulation is made, so that the information may help the formulation persons also. |
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Helmut ★★★   Vienna, Austria, 2006-07-15 15:47 (6873 d 00:55 ago) @ velupharm Posting: # 172 Views: 10,846 |
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Hello Velupharm, if you are interested in 'real data', the 'Enterion' Capsule may be an option. The capsule releases the drug triggered by a radio signal at any part of the GIT. Article by Ian Wilding Manufacturer — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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velupharm ☆ 2006-07-17 08:11 (6871 d 08:30 ago) @ Helmut Posting: # 175 Views: 10,168 |
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Dear helmut Thank you for that article link. But i want to know if we can get some predictive data on the same mentioned aspects from the available parameters of the innovators formulation? |
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Helmut ★★★ Vienna, Austria, 2006-07-17 14:58 (6871 d 01:43 ago) @ velupharm Posting: # 176 Views: 10,328 |
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Hello Velupharm! ❝ But i want to know if we can get some predictive data on the same ❝ mentioned aspects from the available parameters of the innovators ❝ formulation? Hhm, in my experience such data only rarely helps. You might get an idea if solution's data are available, but generally the most interesting part in the original application (which you may obtain from US-FDA according to the 'Freedom of Information Act') is ████████████.  — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz