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AngusMcLean ★★ USA, 2017-01-05 22:45 (2521 d 18:31 ago) Posting: # 16933 Views: 8,749 |
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Concerta is a well-known modified release formulation of methylphenidate. Routinely one sees mean plasma concentration time information from studies in the literature. I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values. My interest lies in the variability in individual profile shape. Angus Edit: subject line changed to lower case. Please don't SHOUT ! Please also check the forum policy under "Be nice!" [Ohlbe]. |
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Helmut ★★★   Vienna, Austria, 2017-01-06 02:09 (2521 d 15:06 ago) @ AngusMcLean Posting: # 16934 Views: 7,855 |
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Hi Angus, ❝ I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values. I don’t know any… Maybe John can help? ❝ My interest lies in the variability in individual profile shape. To give you an idea, one of mine (18 male subjects, Concerta 36 mg, fed state [normal breakfast]; d-MPH base by enantioselective GC/MS, LLOQ 49 pg/mL): ![[image]](img/uploaded/image408.png) — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Mahesh M ★ India, 2017-01-06 09:05 (2521 d 08:11 ago) @ Helmut Posting: # 16935 Views: 7,565 |
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Hi, Please see below link hope it will help you. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317218/ Regards Edit: Yet another one not giving individual data Angus is looking for. SCNR [Helmut] |
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AngusMcLean ★★ USA, 2017-01-06 15:23 (2521 d 01:52 ago) @ Helmut Posting: # 16936 Views: 7,545 |
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Helmut: Thank you. Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets. ❝ |
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Helmut ★★★ Vienna, Austria, 2017-01-06 18:19 (2520 d 22:56 ago) @ AngusMcLean Posting: # 16937 Views: 7,573 |
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Hi Angus, ❝ Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets. I know. Sorry, I can’t disclose subjects’ data. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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nobody nothing 2017-01-07 21:32 (2519 d 19:43 ago) @ Helmut Posting: # 16939 Views: 7,488 |
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Hi! When I was youngerTM we used sumfink like this do get to the data http://quadtechassociates.com/freeware.html (or related Excel scripts) SCNR :=) — Kindest regards, nobody |
Ing. Helmut Schütz