AngusMcLean
★★  

USA,
2017-01-05 22:45
(2639 d 00:52 ago)

Posting: # 16933
Views: 8,967
 

 Concerta individual profiles [Study Per­for­mance]

Concerta is a well-known modified release formulation of methylphenidate. Routinely one sees mean plasma concentration time information from studies in the literature. I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values. My interest lies in the variability in individual profile shape.

Angus


Edit: subject line changed to lower case. Please don't SHOUT ! Please also check the forum policy under "Be nice!" [Ohlbe].
Helmut
★★★
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Vienna, Austria,
2017-01-06 02:09
(2638 d 21:28 ago)

@ AngusMcLean
Posting: # 16934
Views: 8,047
 

 Concerta individual profiles

Hi Angus,

❝ I am looking for a reference to a publication where individual plasma concentration information is reported either as individual profiles or individual plasma concentration time values.


I don’t know any… Maybe John can help?

❝ My interest lies in the variability in individual profile shape.


To give you an idea, one of mine (18 male subjects, Concerta 36 mg, fed state [normal breakfast]; d-MPH base by enantio­selective GC/MS, LLOQ 49 pg/mL):

[image]

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

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Mahesh M
★    

India,
2017-01-06 09:05
(2638 d 14:32 ago)

@ Helmut
Posting: # 16935
Views: 7,749
 

 Concerta individual profiles

Hi,

Please see below link hope it will help you.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317218/

Regards


Edit: Yet another one not giving individual data Angus is looking for. SCNR [Helmut]
AngusMcLean
★★  

USA,
2017-01-06 15:23
(2638 d 08:14 ago)

@ Helmut
Posting: # 16936
Views: 7,736
 

 Concerta individual profiles

Helmut: Thank you. Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets.

[image]

Helmut
★★★
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Homepage
Vienna, Austria,
2017-01-06 18:19
(2638 d 05:18 ago)

@ AngusMcLean
Posting: # 16937
Views: 7,759
 

 Concerta individual profiles

Hi Angus,

❝ Your data set as a spaghetti plot looks quite good, but it is difficult to find individual data sets.


I know. Sorry, I can’t disclose subjects’ data.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
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nobody
nothing

2017-01-07 21:32
(2637 d 02:05 ago)

@ Helmut
Posting: # 16939
Views: 7,674
 

 Concerta individual profiles

Hi!

When I was youngerTM we used sumfink like this do get to the data

http://quadtechassociates.com/freeware.html

(or related Excel scripts)

SCNR :=)

Kindest regards, nobody
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