Dhruv Shah
☆    

India,
2016-03-11 04:48
(2959 d 23:19 ago)

Posting: # 16088
Views: 5,632
 

 t1/2 prior to Tmax in BE study [NCA / SHAM]

Post reply
In a recent BE study I observed that t1/2 (1 hrs) was faster than Tmax (1.3 hrs). I wanted to know that what does it mean? Moreover if we analyze the data of individual subjects, the occurrence was more in test as compared to reference product. Do we need any special design precautions in such study?

Edit: Category changed. Please follow the Forum’s Policy. [Helmut]
 
jag009
★★★

NJ,
2016-03-11 21:25
(2959 d 06:42 ago)

@ Dhruv Shah
Posting: # 16098
Views: 4,584
 

 t1/2 prior to Tmax in BE study

Post reply
Hi,

Did you sample PK adequately?

John
 
Dhruv Shah
☆    

India,
2016-03-16 08:01
(2954 d 20:06 ago)

(edited by Ohlbe on 2016-03-16 09:53)
@ jag009
Posting: # 16107
Views: 4,238
 

 t1/2 prior to Tmax in BE study

Post reply

❝ Did you sample PK adequately?


yes John we have taken that precaution to have adequate points near Tmax

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]
 
mittyri
★★  

Russia,
2016-03-11 23:20
(2959 d 04:47 ago)

@ Dhruv Shah
Posting: # 16099
Views: 4,507
 

 t1/2 prior to Tmax in BE study

Post reply
Hi Dhruv Shah,

Please search the forum and you'll find some gems.
—
Kind regards,
Mittyri
 
UA Flag
Activity
 Admin contact
22,986 posts in 4,823 threads, 1,656 registered users;
49 visitors (0 registered, 49 guests [including 2 identified bots]).
Forum time: 05:07 CEST (Europe/Vienna)

Art is “I”; science is “we”.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5