Bioequivalence and Bioavailability Forum • NCA problems in bear

BE-proff
●

2015-08-19 23:46
(3505 d 16:59 ago)

Posting: # 15306
Views: 8,931

NCA problems in bear [🇷 for BE/BA]

Hi All,

I have tried to upload test data into Bear to try NCA but it says that dataset is not complete and analysis can't be processed :confused:

I can't find the mistake :crying:

Please help....

subj seq prd time conc
1 1 1 1 0 0
2 1 1 1 1 10
3 1 1 1 2 20
4 1 1 1 3 30
5 2 2 1 0 0
6 2 2 1 1 10
7 2 2 1 2 20
8 2 2 1 3 30
9 1 2 2 0 0
10 1 2 2 1 11
11 1 2 2 2 22
12 1 2 2 3 34
13 2 1 2 0 0
14 2 1 2 1 12
15 2 1 2 2 24
16 2 1 2 3 31

The Subject codes of taking Ref. product are as follows:
-------------------------------------------------------------
[1] 1

The Subject codes of taking Tets product are as follows:
-------------------------------------------------------------
[1] 2

The input data could be an incomplete dataset,
i.e., 'Subj of taking R' is not exactly same as 'Subj of taking Test'.
At the moment, bear cannot analyze an incomplete dataset.

Please Enter to go back the Top menu...

yjlee168
★★★

Kaohsiung, Taiwan,
2015-08-20 00:19
(3505 d 16:25 ago)

@ BE-proff
Posting: # 15307
Views: 7,708

check your dataset

Post reply

Dear BE-proff,

Should you data be like this?

subj seq prd time conc

1  1 1 1 0  0

2  1 1 1 1 10

3  1 1 1 2 20

4  1 1 1 3 30

5  2 2 1 0  0

6  2 2 1 1 10

7  2 2 1 2 20

8  2 2 1 3 30

9  1 1 2 0  0

10 1 1 2 1 11

11 1 1 2 2 22

12 1 1 2 3 34

13 2 2 2 0  0

14 2 2 2 1 12

15 2 2 2 2 24

16 2 2 2 3 31

instead of this? :confused:

❝ subj seq prd time conc

❝ ...

❝ 7 2 2 1 2 20

❝ 8 2 2 1 3 30

❝ 9 1 2 2 0 0

❝ 10 1 2 2 1 11

❝ 11 1 2 2 2 22

❝ 12 1 2 2 3 34

❝ 13 2 1 2 0 0

❝ 14 2 1 2 1 12

❝ 15 2 1 2 2 24

❝ 16 2 1 2 3 31

However, I doubt that you can do NCA further since your dataset looks weird or funny for me. Cheer up.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

BE-proff ● 2015-08-20 00:34 (3505 d 16:10 ago) @ yjlee168 Posting: # 15308 Views: 7,706	check your dataset Post reply
	Hi yjlee168, Certainly, these figures are fake and I use them just for training Step by step I will take actual data Thank you

yjlee168
★★★

Kaohsiung, Taiwan,
2015-08-20 01:24
(3505 d 15:20 ago)

@ BE-proff
Posting: # 15309
Views: 7,749

learn bear from running demo (dataset)

Post reply

Dear BE-proff,

OK, I see. No problem. I would like to suggest that you may learn bear more quickly from running demo dataset. Then browse all output files generated after each demo run. All output files can be found in your working directory. You can type getwd() under R console to find where it is.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

BE-proff ● 2015-08-20 10:50 (3505 d 05:54 ago) @ yjlee168 Posting: # 15310 Views: 7,638	learn bear from running demo (dataset) Post reply
	Dear yjlee168, Yesterday I changed data and I obtained PK-results (the 1st victory!) So, next time I will upload real data BTW, is it possible to change current settings? May be I need to compute a design different from default one?

yjlee168
★★★

Kaohsiung, Taiwan,
2015-08-20 11:08
(3505 d 05:36 ago)

@ BE-proff
Posting: # 15311
Views: 7,590

search the Forum first

Post reply

Dear BE-proff,

Have you read Helmut's excellent post in this thread about how to set up bear? Yes, of course it is possible. Please remember to search the Forum first before posting your question. Thanks.

❝ BTW, is it possible to change current settings?

❝ May be I need to compute a design different from default one? ;-)

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

BE-proff ● 2015-08-21 14:45 (3504 d 01:59 ago) @ yjlee168 Posting: # 15319 Views: 7,491	check your dataset Post reply
	Dear yjlee168, Could please explain again. If I have 5 subjects for analysis (i.e. I will add # 3, 4, 5) how the table for bear will look? In other words, how to add additional subjects to your corrected example? Thank you

yjlee168
★★★

Kaohsiung, Taiwan,
2015-08-21 18:06
(3503 d 22:38 ago)

@ BE-proff
Posting: # 15320
Views: 7,531

prepare dataset for bear

Post reply

Dear BE-proff,

I will suggest the following ways to prepare dataset for bear:

first visit bear's website (here) and read from the section of '...Sample file of the imported data format (.csv)...' carefully and patiently;
Run library(bear), and when the menu appears, select *Export all demo dataset (shown as picture). It will finish very quickly. Then go to your working directory to browse all these exported dataset, especially *.csv files. You should be able to figure out what they are for very easily by their file names. Use a plain text editor or a spreadsheet program (such as Gnumeric or LibreOffice Calc or MS-Excel) to open these files. It can give you some clues about how to prepare dataset for bear.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here