Bioequivalence and Bioavailability Forum • Bioequivalence Code for SAS

Emrah Soner Özdeş
☆

Turkey,
2015-01-16 15:52
(3559 d 19:37 ago)

Posting: # 14299
Views: 7,560

Bioequivalence Code for SAS [Software]

Hi All;

I normally conclude BE with WNL and R. Yet my manager is big fan of SAS and wants the BE results as SAS output as well.

I have the code for ANOVA models as described in Guidances and able to obtain 90% Confidence Limits for differences with LSMEANS as you may see below.

[image]

As a final step LSMean(i)-LSMean(j) values should be antilogged and multiplied with 100 to obtain upper and lower limits.

What I wonder is how may I code this last step so that it can be included in the SAS Output. Any help will be appreciated.

Regards

d_labes
★★★

Berlin, Germany,
2015-01-19 09:20
(3557 d 02:09 ago)

@ Emrah Soner Özdeş
Posting: # 14301
Views: 6,019

Bioequivalence Code for SAS

Post reply

Dear Emrah!

❝ As a final step LSMean(i)-LSMean(j) values should be antilogged and multiplied with 100 to obtain upper and lower limits.

❝

❝ What I wonder is how may I code this last step so that it can be included in the SAS Output. Any help will be appreciated.

The short answer: Ask your big SAS fan :-D

.

To be serious:
I suppose you are using Proc GLM.
Place an ODS output statement before or within the Proc GLM code.
Something like:

ODS output LSMeanDiffCL=whatever_you_like_as_name;

Take the dataset whatever_you_like_as_name and perform the back-transformation.
The relevant varibles are diff, lowerCL, upperCL if I recall correctly. Take care of the order of treatm the diff and its CI will be calculated and change sign if necessary.

A simple Proc Print call will show you the results.

BTW: How did you arrive at T-R (i=2, j=1)? Mine is always R-T if treatm is coded that way due to lexical ordering.

Hope this helps

—
Regards,

Detlew

Emrah Soner Özdeş
☆

Turkey,
2015-01-20 14:12
(3555 d 21:17 ago)

@ d_labes
Posting: # 14305
Views: 5,949

Bioequivalence Code for SAS

Post reply

Hey Detlew;

Thanks for your help. I finally made it by searching through some SAS tutorials.
By ODS tracing I obtained the label of table, created a data set, and performed some math on the parameters and finally printed.

❝ BTW: How did you arrive at T-R (i=2, j=1)? Mine is always R-T if treatm is coded that way due to lexical ordering.

As I said SAS is not my favorite thing to work with. Yet, here is the PROC GLM of my code. Hope this helps:

[image]

Regards

Emrah

jishnu ☆ India, 2022-08-06 21:02 (800 d 15:27 ago) @ Emrah Soner Özdeş Posting: # 23205 Views: 2,037	Bioequivalence Code for SAS Post reply
	Hi Emrah, have some doubts. please message me on +91 9074206778. regards, Jishnu prasad Mumbai, India. Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]