mahendra
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US,
2013-10-24 18:10
(4008 d 15:12 ago)

Posting: # 11753
Views: 40,005
 

 IVIVC calculations [Dissolution / BCS / IVIVC]

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Hi
I am working in analytical method development for Pharmaceutical company.

I want to just learn how to do IVIVC comparison.

For a Batch of drug product:

for Invitro: data: % drug dissolved in 15 min, 30 min, 45 min intervals.
For invivo: What data do i need ? Like AUC, Cmax etc.

I am unbale to see examples on this. Colud any one help me to learn this? Its my interest.

I have Minitab 16: is it capble to IVIVC?

I see recently in a post that mentioned IVIVC is possible in R software? I dont know about R software and i have not used it? Is it simple to run IVIVC in R to learn?

I want to see practically how IVIVC data give the information for next development?

Thanks in advance
 
yjlee168
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Kaohsiung, Taiwan,
2013-10-24 21:22
(4008 d 12:00 ago)

@ mahendra
Posting: # 11758
Views: 37,178
 

 IVIVC calculations

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Hi again,

Search this forum first (tons of previous discussion about this topic in this Forum) and then ask master Google if necessary.

❝ I am working in analytical method development for Pharmaceutical company.

❝

❝ I want to just learn how to do IVIVC comparison.

❝

❝ For a Batch of drug product:

❝

❝ for Invitro: data: % drug dissolved in 15 min, 30 min, 45 min intervals.


You will need dissolution profile data for 3-6 solid dosage forms with different release rates. More is better. Leave one solid dosage form for external validation if you like to do so. Otherwise, you can use internal validation with all solid dosage forms. Your planned sampling time (15 min, 30 min and 45 min) should be more. Don't forget that these are all MR (not IR) dosage forms.

❝ For invivo: What data do i need ? Like AUC, Cmax etc.


for kel (not ka!) estimation: dose iv/solution/suspension (one of these) dosage forms to estimate ka for each subject.

for ivivc model: to dose previously mentioned solid dosage forms of various release rates to each subject.

❝ I have Minitab 16: is it capble to IVIVC?


It should be able to do the job. Very nice stat computer program. But I don't have any experience with it.

❝ I see recently in a post that mentioned IVIVC is possible in R software?


Yes, you can browse CRAN near you and look at (and search) the packages. There are Rivivc and ivivc. Pick what you need.

❝ I dont know about R software and ihave not used it? Is it simple to run IVIVC in R to learn?


Of course, it is very simple for a pharmaceutical scientist. UseR!

❝ I want to see practically how IVIVC data give the information for next development?


:confused: I don't quite get your point here. Sorry about that.
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mahendra
☆    

US,
2013-10-24 21:45
(4008 d 11:37 ago)

@ yjlee168
Posting: # 11759
Views: 37,112
 

 IVIVC calculations

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Hi yjlee168

Thank you very much

❝ ❝ I want to see practically how IVIVC data give the information for next development?

❝

❝ :confused: I don't quite get your point here. Sorry about that.


Could you plz develop an example with hypothetical data for invivo and invitro for an IR, MR formulation and analysis in excel.

Mahendra
 
yjlee168
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Kaohsiung, Taiwan,
2013-10-25 00:21
(4008 d 09:01 ago)

@ mahendra
Posting: # 11760
Views: 37,207
 

 IVIVC calculations

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Dear Mahendra,

If you really like to use excel, you can ask Gohel M, et. al. [quoted from their website]... A copy of EXCEL worksheet can be obtained from the authors upon request...

The following simulated data are obtained from ivivc package.
pk original data (dose = 100)for estimate 'kel' (as well as 'ka' and 'Vd') are

subj time    conc 
   1  0.0 0.00000 
   1  0.5 0.35389 
   1  1.0 0.29890 
   1  1.5 0.27296 
   1  2.0 0.20250 
   1  3.0 0.09352 
   1  4.0 0.07649 
   1  5.0 0.05756 
   1  6.0 0.04223 
   1  8.0 0.03120 
   1 10.0 0.01482 
   2  0.0 0.00000 
   2  0.5 0.33420 
   2  1.0 0.26397 
   2  1.5 0.16668 
   2  2.0 0.15359 
   2  3.0 0.07647 
   2  4.0 0.04367 
   2  5.0 0.01475 
   2  6.0 0.01742 
   2  8.0 0.00996 
   2 10.0 0.00389 
   3  0.0 0.00000 
   3  0.5 0.35389 
   3  1.0 0.23890 
   3  1.5 0.14296 
   3  2.0 0.12504 
   3  3.0 0.06052 
   3  4.0 0.03649 
   3  5.0 0.00756 
   3  6.0 0.00223

ps. this dataset is obtained from solution or suspension dosage form.

The in-vivo (conc. obs) and in-vitro (FRD, cumulative release fraction (%)) data vs. time with two different pH (1.2 & 6.8) media are

 pH  formula subject time conc.obs    FRD
1.2        S       1  0.0  0.00000   0.00
1.2        S       1  0.5  0.02265  17.17
1.2        S       1  1.0  0.03262  19.63
1.2        S       1  1.5  0.05025  24.81
1.2        S       1  2.0  0.05025  30.38
1.2        S       1  3.0  0.13061  35.01
1.2        S       1  4.0  0.12923  40.60
1.2        S       1  5.0  0.12883  47.86
1.2        S       1  6.0  0.07619  54.07
1.2        S       1  8.0  0.04683  64.59
1.2        S       1 10.0  0.02390  72.49
1.2        S       1 12.0  0.02043  78.66
1.2        S       1 24.0  0.01746  98.05
1.2        S       2  0.0  0.00000   0.00
1.2        S       2  0.5  0.22248  13.23
1.2        S       2  1.0  0.24437  20.08
1.2        S       2  1.5  0.24437  26.41
1.2        S       2  2.0  0.27090  33.15
1.2        S       2  3.0  0.13900  40.52
1.2        S       2  4.0  0.13900  46.08
1.2        S       2  5.0  0.08430  55.70
1.2        S       2  6.0  0.06942  59.05
1.2        S       2  8.0  0.06991  69.74
1.2        S       2 10.0  0.07202  77.60
1.2        S       2 12.0  0.07862  84.47
1.2        S       2 24.0  0.02330 101.38
1.2        S       3  0.0  0.00000   0.00
1.2        S       3  0.5  0.05093  13.46
1.2        S       3  1.0  0.06240  21.23
1.2        S       3  1.5  0.11309  27.78
1.2        S       3  2.0  0.07568  34.41
1.2        S       3  3.0  0.15707  42.03
1.2        S       3  4.0  0.10396  47.58
1.2        S       3  5.0  0.06907  55.07
1.2        S       3  6.0  0.04574  62.72
1.2        S       3  8.0  0.04443  73.18
1.2        S       3 10.0  0.03608  80.52
1.2        S       3 12.0  0.01893  86.65
1.2        S       3 24.0  0.01353 101.65
1.2        M       1  0.0  0.00000   0.00
1.2        M       1  0.5  0.10740  16.70
1.2        M       1  1.0  0.15168  21.24
1.2        M       1  1.5  0.18293  27.10
1.2        M       1  2.0  0.21175  35.42
1.2        M       1  3.0  0.14171  41.53
1.2        M       1  4.0  0.13102  49.33
1.2        M       1  5.0  0.14073  56.06
1.2        M       1  6.0  0.14073  53.36
1.2        M       1  8.0  0.08957  71.22
1.2        M       1 10.0  0.05584  80.03
1.2        M       1 12.0  0.07919  84.48
1.2        M       1 24.0  0.01353 100.22
1.2        M       2  0.0  0.00000   0.00
1.2        M       2  0.5  0.12390  14.16
1.2        M       2  1.0  0.16241  21.23
1.2        M       2  1.5  0.12500  27.10
1.2        M       2  2.0  0.12500  34.91
1.2        M       2  3.0  0.14800  42.53
1.2        M       2  4.0  0.16100  48.83
1.2        M       2  5.0  0.12800  55.81
1.2        M       2  6.0  0.13200  61.00
1.2        M       2  8.0  0.12800  71.47
1.2        M       2 10.0  0.08904  78.58
1.2        M       2 12.0  0.02400  84.25
1.2        M       2 24.0  0.01710  99.54
1.2        M       3  0.0  0.00000   0.00
1.2        M       3  0.5  0.12700  13.69
1.2        M       3  1.0  0.14000  21.00
1.2        M       3  1.5  0.10400  26.41
1.2        M       3  2.0  0.10300  34.91
1.2        M       3  3.0  0.16631  43.53
1.2        M       3  4.0  0.16351  49.08
1.2        M       3  5.0  0.16351  55.07
1.2        M       3  6.0  0.11862  60.75
1.2        M       3  8.0  0.12589  69.03
1.2        M       3 10.0  0.06181  76.16
1.2        M       3 12.0  0.03234  81.84
1.2        M       3 24.0  0.01901  97.20
1.2        F       1  0.0  0.00000   0.00
1.2        F       1  0.5  0.11026  11.14
1.2        F       1  1.0  0.11617  13.86
1.2        F       1  1.5  0.13020  18.84
1.2        F       1  2.0  0.14577  19.79
1.2        F       1  3.0  0.12375  25.97
1.2        F       1  4.0  0.12305  32.09
1.2        F       1  5.0  0.08235  37.16
1.2        F       1  6.0  0.04862  41.44
1.2        F       1  8.0  0.02651  50.12
1.2        F       1 10.0  0.00304  54.28
1.2        F       1 12.0  0.00287  59.81
1.2        F       1 24.0  0.00274  84.53
1.2        F       2  0.0  0.00000   0.00
1.2        F       2  0.5  0.12571   9.75
1.2        F       2  1.0  0.08260  13.63
1.2        F       2  1.5  0.15150  18.38
1.2        F       2  2.0  0.07328  23.56
1.2        F       2  3.0  0.05693  27.72
1.2        F       2  4.0  0.06357  34.83
1.2        F       2  5.0  0.04843  39.39
1.2        F       2  6.0  0.08606  43.66
1.2        F       2  8.0  0.07116  52.33
1.2        F       2 10.0  0.04743  57.43
1.2        F       2 12.0  0.02257  62.70
1.2        F       2 24.0  0.00882  85.53
1.2        F       3  0.0  0.00000   0.00
1.2        F       3  0.5  0.16745   9.75
1.2        F       3  1.0  0.12430  13.86
1.2        F       3  1.5  0.13227  17.92
1.2        F       3  2.0  0.11946  21.55
1.2        F       3  3.0  0.06243  26.47
1.2        F       3  4.0  0.04864  32.59
1.2        F       3  5.0  0.06557  36.91
1.2        F       3  6.0  0.05926  40.94
1.2        F       3  8.0  0.04277  49.63
1.2        F       3 10.0  0.03909  53.07
1.2        F       3 12.0  0.02206  58.84
1.2        F       3 24.0  0.01088  81.53
6.8        S       1  0.0  0.00000   0.00
6.8        S       1  0.5  0.02265  13.46
6.8        S       1  1.0  0.03262  19.60
6.8        S       1  1.5  0.05025  24.80
6.8        S       1  2.0  0.05025  30.63
6.8        S       1  3.0  0.13061  36.51
6.8        S       1  4.0  0.12923  42.59
6.8        S       1  5.0  0.12883  49.35
6.8        S       1  6.0  0.07619  56.04
6.8        S       1  8.0  0.04683  66.31
6.8        S       1 10.0  0.02390  74.42
6.8        S       1 12.0  0.02043  81.06
6.8        S       1 24.0  0.01746  99.69
6.8        S       2  0.0  0.00000   0.00
6.8        S       2  0.5  0.22248  14.62
6.8        S       2  1.0  0.24437  21.70
6.8        S       2  1.5  0.24437  28.70
6.8        S       2  2.0  0.27090  35.42
6.8        S       2  3.0  0.13900  43.79
6.8        S       2  4.0  0.13900  48.09
6.8        S       2  5.0  0.08430  54.83
6.8        S       2  6.0  0.06942  61.00
6.8        S       2  8.0  0.06991  70.98
6.8        S       2 10.0  0.07202  78.83
6.8        S       2 12.0  0.07862  84.73
6.8        S       2 24.0  0.02330 100.91
6.8        S       3  0.0  0.00000   0.00
6.8        S       3  0.5  0.05093  11.14
6.8        S       3  1.0  0.06240  17.32
6.8        S       3  1.5  0.11309  22.51
6.8        S       3  2.0  0.07568  28.10
6.8        S       3  3.0  0.15707  35.50
6.8        S       3  4.0  0.10396  39.09
6.8        S       3  5.0  0.06907  45.12
6.8        S       3  6.0  0.04574  52.33
6.8        S       3  8.0  0.04443  59.94
6.8        S       3 10.0  0.03608  67.63
6.8        S       3 12.0  0.01893  73.82
6.8        S       3 24.0  0.01353  91.71
6.8        M       1  0.0  0.00000   0.00
6.8        M       1  0.5  0.10740  16.94
6.8        M       1  1.0  0.15168  22.85
6.8        M       1  1.5  0.18293  27.10
6.8        M       1  2.0  0.21175  35.17
6.8        M       1  3.0  0.14171  41.03
6.8        M       1  4.0  0.13102  48.59
6.8        M       1  5.0  0.14073  56.06
6.8        M       1  6.0  0.14073  60.76
6.8        M       1  8.0  0.08957  69.28
6.8        M       1 10.0  0.05584  77.14
6.8        M       1 12.0  0.07919  83.04
6.8        M       1 24.0  0.01353  98.36
6.8        M       2  0.0  0.00000   0.00
6.8        M       2  0.5  0.12390  15.55
6.8        M       2  1.0  0.16241  21.93
6.8        M       2  1.5  0.12500  21.83
6.8        M       2  2.0  0.12500  36.17
6.8        M       2  3.0  0.14800  44.53
6.8        M       2  4.0  0.16100  49.08
6.8        M       2  5.0  0.12800  55.32
6.8        M       2  6.0  0.13200  61.49
6.8        M       2  8.0  0.12800  69.52
6.8        M       2 10.0  0.08904  76.65
6.8        M       2 12.0  0.02400  83.04
6.8        M       2 24.0  0.01710  98.83
6.8        M       3  0.0  0.00000   0.00
6.8        M       3  0.5  0.12700  13.69
6.8        M       3  1.0  0.14000  20.31
6.8        M       3  1.5  0.10400  25.95
6.8        M       3  2.0  0.10300  33.65
6.8        M       3  3.0  0.16631  42.03
6.8        M       3  4.0  0.16351  46.83
6.8        M       3  5.0  0.16351  52.83
6.8        M       3  6.0  0.11862  58.28
6.8        M       3  8.0  0.12589  67.79
6.8        M       3 10.0  0.06181  76.63
6.8        M       3 12.0  0.03234  83.02
6.8        M       3 24.0  0.01901  98.12
6.8        F       1  0.0  0.00000   0.00
6.8        F       1  0.5  0.11026   8.83
6.8        F       1  1.0  0.11617  14.09
6.8        F       1  1.5  0.13020  17.69
6.8        F       1  2.0  0.14577  20.79
6.8        F       1  3.0  0.12375  25.71
6.8        F       1  4.0  0.12305  31.34
6.8        F       1  5.0  0.08235  35.67
6.8        F       1  6.0  0.04862  40.20
6.8        F       1  8.0  0.02651  48.40
6.8        F       1 10.0  0.00304  55.72
6.8        F       1 12.0  0.00287  61.48
6.8        F       1 24.0  0.00274  81.08
6.8        F       2  0.0  0.00000   0.00
6.8        F       2  0.5  0.12571   9.06
6.8        F       2  1.0  0.08260  14.32
6.8        F       2  1.5  0.15150  18.38
6.8        F       2  2.0  0.07328  21.55
6.8        F       2  3.0  0.05693  26.97
6.8        F       2  4.0  0.06357  33.33
6.8        F       2  5.0  0.04843  38.15
6.8        F       2  6.0  0.08606  43.41
6.8        F       2  8.0  0.07116  51.59
6.8        F       2 10.0  0.04743  57.91
6.8        F       2 12.0  0.02257  63.42
6.8        F       2 24.0  0.00882  82.51
6.8        F       3  0.0  0.00000   0.00
6.8        F       3  0.5  0.16745   9.99
6.8        F       3  1.0  0.12430  13.40
6.8        F       3  1.5  0.13227  17.23
6.8        F       3  2.0  0.11946  18.78
6.8        F       3  3.0  0.06243  24.46
6.8        F       3  4.0  0.04864  30.34
6.8        F       3  5.0  0.06557  34.92
6.8        F       3  6.0  0.05926  38.96
6.8        F       3  8.0  0.04277  47.42
6.8        F       3 10.0  0.03909  54.98
6.8        F       3 12.0  0.02206  60.51
6.8        F       3 24.0  0.01088  81.53

ps. with the same dose of 100 here.
where S: slow release; M: median release, F: fast release
These are just simulated data. You may need more subjects for in-vivo test and/or more pH and add more dosage forms with different release rates (such as "very slow", "very fast") for in-vitro test. I don't know if this is what you need or not. Please consult with official guidelines/guidance for more details in study design of ivivc. That's very mandatory. The information here is very, very brief! If you have budget, you can also consider the commercial computer program- IVIVC TOOLKIT from CERTARA (used to be Pharsight?).

❝ Could you plz develop an example with hypothetical data for invivo and invitro for an IR, MR formulation and analysis in excel.

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
Helmut
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2013-10-25 16:38
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@ yjlee168
Posting: # 11766
Views: 37,016
 

 Mergers

Post reply
Hi Yung-jin,

❝ […] the commercial computer program- IVIVC TOOLKIT from CERTARA (used to be Pharsight?).


Pharsight was acquired by Tripos (itself belonging to Certara) some years ago. Now the official name is “Pharsight, a Certara Company”. ;-)
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mahendra
☆    

US,
2013-10-25 18:49
(4007 d 14:33 ago)

@ yjlee168
Posting: # 11773
Views: 36,517
 

 IVIVC calculations

Post reply
Hi yjlee

Thankyou very much.
 
yjlee168
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Kaohsiung, Taiwan,
2013-10-27 06:41
(4006 d 01:41 ago)

@ mahendra
Posting: # 11779
Views: 36,897
 

 PCDCON ⇒ IVIVC calculations

Post reply
Hi mahendra,

One more choice for ivivc that I almost forget: PCDCON if you like to take a look. You can download it from this Forum (here). It's freeware too. It can do numerical convolution/deconvolution. Please note that it is a 16-bit DOS computer program written with FORTRAN-77. However, you can run it on a 32-bit Windows OS under DOS command line mode. It will fail on a x64 Windows OS. Hope this can help.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
 
thalita_m
☆    

Brazil,
2019-06-18 04:51
(1946 d 04:31 ago)

@ yjlee168
Posting: # 20331
Views: 17,989
 

 IVIVC calculations

Post reply

❝ If you really like to use excel, you can ask Gohel M, et. al. [quoted from their website]... A copy of EXCEL worksheet can be obtained from the authors upon request...


Hi Mr. Yung-jin Lee,

You recommend me this article! I request the Excel worksheet but the authors did not answer to my request. Did you have this worksheet ?

Thank you.
Thalita
 
jag009
★★★

NJ,
2013-10-25 01:17
(4008 d 08:05 ago)

@ mahendra
Posting: # 11762
Views: 37,120
 

 IVIVC calculations

Post reply
Hi,

❝ I want to just learn how to do IVIVC comparison.


I suggest you to go to pubmed and search for articles on IVIVC. There are a number of them. (Yes the articles exist) You need to understand the background first. Diving straight into R with not help you and would probably end up with more fustrations...

❝ I have Minitab 16: is it capble to IVIVC?


No.

John
 
Helmut
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Vienna, Austria,
2013-10-25 16:43
(4007 d 16:39 ago)

@ jag009
Posting: # 11767
Views: 37,280
 

 Minitab etc.

Post reply
Hi John,

❝ ❝ I have Minitab 16: is it capble to IVIVC?

❝

❝ No.


“Out of the box”: No. But it would be possible to code IVIVC in it – like in any other statistical software. If you know the formulas and have a lot of time even paper/pencil/brain would do the job. ;-)
—
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jag009
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NJ,
2013-10-25 18:27
(4007 d 14:55 ago)

@ Helmut
Posting: # 11770
Views: 36,969
 

 Minitab etc.

Post reply
Hi Helmut,

❝ “Out of the box”: No. But it would be possible to code IVIVC in it – like in any other statistical software. If you know the formulas and have a lot of time even paper/pencil/brain would do the job. ;-)


Amount of time needed = infinity? :-|
Heck you might as well do it in Excel (don't laugh, there are papers out there for IVIVC in excel. Langenbucher wrote a few papers on this).

Jon
 
Helmut
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Vienna, Austria,
2013-10-25 18:38
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@ jag009
Posting: # 11771
Views: 36,664
 

 XL

Post reply
Hi John,

❝ Amount of time needed = infinity? :-|


≠ ∞, but very long. Errors likely. I would suggest to perform the calculations at least twice. ;-)

❝ Heck you might as well do it in Excel (don't laugh, there are papers out there for IVIVC in excel. Langenbucher wrote a few papers on this).


I know. I got one Excel-sheet from Jean-Michel Cardot (who worked together with Frieder Langenbucher in Basel). He uses it in his workshops but always switches to the cell-formulas in order to show how nasty that is. It is too easy to screw up the cell-references when adding rows/columns… BTW, he also has set up IVIVC in SAS. Not an easy task as well. By far less error-prone, but still a lot of code.
—
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Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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jag009
★★★

NJ,
2013-10-28 21:42
(4004 d 10:40 ago)

@ Helmut
Posting: # 11800
Views: 36,249
 

 XL

Post reply
Hi Helmut,

❝ I know. I got one Excel-sheet from Jean-Michel Cardot (who worked together with Frieder Langenbucher in Basel). He uses it in his workshops but always switches to the cell-formulas in order to show how nasty that is. It is too easy to screw up the cell-references when adding rows/columns… BTW, he also has set up IVIVC in SAS. Not an easy task as well. By far less error-prone, but still a lot of code.


Actually I followed Langenbucher's papers and drafted up the excel spreadsheet myself. I used data from an older IVIVC study report, fooled around with my newly made excel spreadsheet, and it worked perfectly! (Granted that during the spreadsheet development my boss complained about my verbal use of explicit english vocabularies) :-D.

John
 
luvblooms
★★  

India,
2013-10-29 06:08
(4004 d 02:14 ago)

@ jag009
Posting: # 11801
Views: 36,279
 

 XL

Post reply
Dear John!!!

❝ Actually I followed Langenbucher's papers and drafted up the excel spreadsheet myself. I used data from an older IVIVC study report, fooled around with my newly made excel spreadsheet, and it worked perfectly!


I tried to follow Langenbucher's paper and was able to make some examples what he mentioned in Paper I and II but failed miserably when I tried his paper no III and IV (mainy the convolution part).

Looks like I got a teacher ;-). Any id for direct message?

Regards
Luv
—
~A happy Soul~
 
jag009
★★★

NJ,
2013-10-29 16:07
(4003 d 16:15 ago)

@ luvblooms
Posting: # 11804
Views: 36,177
 

 XL

Post reply
Hi Luvbloom,

Where did you get stuck specifically? I ran the exercise myself about 4-5 yrs ago because we wanted to make a IVIVC program (with my former post-doc friend) for internal use so I don't remember the full details (need to think back...). Did you take into account the time scaling?

John
 
luvblooms
★★  

India,
2013-10-30 08:00
(4003 d 00:22 ago)

@ jag009
Posting: # 11810
Views: 36,404
 

 XL

Post reply
Hi John

❝ Where did you get stuck specifically?


I got stuck in the the third paper "Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: III. Convolution and deconvolution" specially with the system analysis and functional convolution

❝ I ran the exercise myself about 4-5 yrs ago because we wanted to make a IVIVC program (with my former post-doc friend) for internal use so I don't remember the full details (need to think back...).


Maths and I have never exactly been best friends I guess ;-)

❝ Did you take into account the time scaling?


I was trying to mimic the example given in the paper but no avail!!!
I have prepared my open VB based spread sheet where it take cares of Time scaling and all but still not able to work on convolution for prediction purpose.

I have started working on it again just to make sure I have not forgot the basics.

P.S: If you get time do read this BIOEQUIVALENCE STUDY OF OMEPRAZOLE CAPSULE: IN VITRO IN VIVO :-D

Regards
—
~A happy Soul~
 
Helmut
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Vienna, Austria,
2013-10-30 15:40
(4002 d 16:42 ago)

@ luvblooms
Posting: # 11816
Views: 36,170
 

 Broken link

Post reply
Hi Luv,

❝ If you get time do read this BIOEQUIVALENCE STUDY OF OMEPRAZOLE CAPSULE: IN VITRO IN VIVO


→ Service Unavailable

From [image]’s cache I gather it is
Somnath Sakore and Bhaswat Chakraborty
International Journal of Universal Pharmacy and Life Sciences 2(1): January-February 2012, 37–47

Unfortunately I don’t find the paper in the journal’s archive.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
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jag009
★★★

NJ,
2013-10-30 17:35
(4002 d 14:47 ago)

(edited on 2013-10-30 19:21)
@ luvblooms
Posting: # 11821
Views: 36,048
 

 XL

Post reply
Hi Luvbloom,

Can you post the data that you obtain from the article so I can goof around? (see if you can get an abstract posted here as well)

I don't have access to that article.


John
 
luvblooms
★★  

India,
2013-10-31 09:15
(4001 d 23:06 ago)

@ jag009
Posting: # 11834
Views: 35,875
 

 XL

Post reply
Hey John and Helmut

❝ I don't have access to that article.

❝ Unfortunately I don’t find the paper in the journal’s archive.


Looks like it has been removed or something.
I had some serious doubt on the methods mentiod in the paper and I wrote to the author as well but all mails bounced back.
And the major concern was on two points
  1. The way time scaling was done (it was mentioned as an intensity factor in the paper)
  2. % Absorbed was 10% higher than % release ;-)

Let me check if I can get it in my database.


Regards
—
~A happy Soul~
 
jag009
★★★

NJ,
2013-10-31 21:31
(4001 d 10:51 ago)

@ luvblooms
Posting: # 11848
Views: 35,967
 

 XL

Post reply
Hi Luvbloom,

I know one of the authors (the 2nd one). We worked together before. Maybe I can catch him via email. Anyhow, let me know if you have access in your database. I recall seeing a paper on Omeprazole IVIVC but I can't find it.

John
 
jag009
★★★

NJ,
2013-11-06 17:44
(3995 d 14:38 ago)

@ luvblooms
Posting: # 11864
Views: 35,752
 

 Any news?

Post reply
Hi Luvbloom,

❝ Looks like it has been removed or something.

❝ I had some serious doubt on the methods mentiod in the paper and I wrote to the author as well but all mails bounced back.

❝ And the major concern was on two points

  1. The way time scaling was done (it was mentioned as an intensity factor in the paper)

    ❝

  2. % Absorbed was 10% higher than % release ;-)

❝ Let me check if I can get it in my database.


Any news on the paper? Now you got me interested again :-)

Thanks

John
 
luvblooms
★★  

India,
2013-11-07 11:50
(3994 d 20:32 ago)

@ jag009
Posting: # 11865
Views: 35,849
 

 Good News

Post reply
Hi John

Got the paper!!
But where to share?


Regards
—
~A happy Soul~
 
jag009
★★★

NJ,
2013-11-27 17:44
(3974 d 14:38 ago)

@ luvblooms
Posting: # 11982
Views: 35,510
 

 PBPK IVIVC

Post reply
Hi Luvbloom,

Take a look at Certara's SIMCYP website. They have a poster on IVIVC based on PBPK modelling, quite interesting. The poster only have limited info though.

John
 
luvblooms
★★  

India,
2013-11-27 20:31
(3974 d 11:51 ago)

@ jag009
Posting: # 11983
Views: 35,413
 

 PBPK IVIVC

Post reply
Hey John

You talking about this or this?

Or something different?

Regards
—
~A happy Soul~
 
jag009
★★★

NJ,
2013-11-27 21:04
(3974 d 11:18 ago)

@ luvblooms
Posting: # 11985
Views: 35,432
 

 PBPK IVIVC

Post reply
Hi Luvbloom,

❝ Or something different?


Yes the 2nd one. I was at AAPS but didn't really get a chance to talk to the presenter but I sort of have an idea. I would like to see them apply it to other BCS classes though (maybe not 3 and 4)...

John
 
jag009
★★★

NJ,
2013-11-28 07:01
(3974 d 01:21 ago)

@ luvblooms
Posting: # 11986
Views: 35,527
 

 Good News

Post reply
Hi Luvbloom,

❝ Got the paper!!

❝ But where to share?


Check your personal email. I sent a message to you. You can email me the paper.

Thanks

John
 
Helmut
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Vienna, Austria,
2013-11-07 15:50
(3994 d 16:32 ago)

@ jag009
Posting: # 11866
Views: 35,701
 

 Contact

Post reply
Hi John,

❝ Any news on the paper? Now you got me interested again :-)


You may contact Luv by means of the secure web-form. Just click [image] here. There you can give your e-mail address & he might contact you directly.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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jag009
★★★

NJ,
2013-11-27 17:42
(3974 d 14:40 ago)

@ Helmut
Posting: # 11981
Views: 35,355
 

 Contact

Post reply
Thanks Helmut.

John
 
thalita_m
☆    

Brazil,
2019-06-18 04:46
(1946 d 04:36 ago)

@ jag009
Posting: # 20330
Views: 17,859
 

 XL

Post reply

❝ ❝ I got one Excel-sheet from Jean-Michel Cardot…

❝

❝ Actually I followed Langenbucher's papers and drafted up the excel spreadsheet myself…


Hi John,

First, sorry to resuscitate this post.
Second, could you please send me the Excel-sheet from Mr. Cardot? Or just an example of it?

Thanks for your help.

Thalita

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
 
Helmut
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Vienna, Austria,
2019-06-18 13:08
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@ thalita_m
Posting: # 20332
Views: 17,648
 

 Jean-Michel

Post reply
Hi Thalita,

THX for editing your personal profile! That’s a rarity. ;-)

Instead of playing Chinese whispers please contact Jean-Michel (j-michel.cardot[image]uca.fr) directly.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
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thalita_m
☆    

Brazil,
2019-06-21 00:18
(1943 d 09:04 ago)

@ Helmut
Posting: # 20351
Views: 17,695
 

 Jean-Michel

Post reply

❝ Instead of playing Chinese whispers please contact Jean-Michel (j-michel.cardot[image]uca.fr) directly.


Hi Helmut,

Thanks for the contact.
I text Mr. Cardot and just got te Excel sheets.

Thank you very much!
 
Abel1972
☆    

Philippines,
2020-06-17 07:28
(1581 d 01:54 ago)

@ thalita_m
Posting: # 21546
Views: 12,656
 

 Jean-Michel

Post reply
Hi Thalita_m,

I'm a beginner in IVIVC and currently doing some readings on the topic. I emailed Mr. Cardot for the files, but apparently the university is closed due to COVID-19. If you currently have access to the Excel files, I am hoping you could share it to me so I could better understand the calculations used. Thanks in advance.

Abel
 
thalita_m
☆    

Brazil,
2022-09-17 07:50
(759 d 01:32 ago)

@ Abel1972
Posting: # 23304
Views: 5,448
 

 Jean-Michel

Post reply
Hi Abel!

❝ I'm a beginner in IVIVC and currently doing some readings on the topic. I emailed Mr. Cardot for the files, but apparently the university is closed due to COVID-19. If you currently have access to the Excel files, I am hoping you could share it to me so I could better understand the calculations used. Thanks in advance.


I hope it was not too late to send you the files, but I was absent from the forum updates! I really sorry for that.
Please, if you still want the Excel files, email me: [email protected]

See you!
 
Achievwin
★★  

US,
2020-06-17 17:00
(1580 d 16:22 ago)

@ Helmut
Posting: # 21548
Views: 12,758
 

 Minitab etc.

Post reply

❝ Out of the box […] and have a lot of time even brain […] would do the job. ;-)


Oh R we still using it? - AW
 
mahendra
☆    

US,
2013-10-25 18:48
(4007 d 14:34 ago)

@ jag009
Posting: # 11772
Views: 36,499
 

 IVIVC calculations

Post reply
Hi John

Thanks
 
vinayshed
☆    

2013-10-28 09:54
(4004 d 22:28 ago)

@ mahendra
Posting: # 11789
Views: 36,329
 

 IVIVC calculations

Post reply
Mahendra

If you really want to understand how to carry out IVIVC, you have to know the basics of it and it can be carried out using Excel. You have to have dissolution data and plasma time vs concn. data. Once you understand the procedure, then you can use any software. Jean Michel Cardot's Excel sheets are good and easy to understand.
 
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