dixit
★    

India,
2009-02-10 06:57
(6349 d 17:05 ago)

Posting: # 3215
Views: 7,565
 

 lansoprazole [Off Topic]

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Dear all good morning,

Can any one tell me what makes Lansoprazole a highly variable drug.

Thanks and Regards
Dixit :-)
 
drcampos
★    

Brazil,
2009-02-10 20:45
(6349 d 03:17 ago)

@ dixit
Posting: # 3219
Views: 6,124
 

 lansoprazole

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Dear Dixit,

Lansoprazole is practically insoluble in water and extensively metabolized in liver. So, these factors may contribute to the high variability of this drug. Moreover, considering the solubility in water (0.97mg/L) and Log P value (1.9) this drug may be provisional classified as BCS class II, therefore the dissolution may be the key factor for its absorption. Generally, BCS class II drugs presents intrasubject variability (CVintra) higher than 30% in bioequivalence studies.

Additional comments will be welcome!

Daniel Rossi de Campos
Brazil
 
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