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jag009 ★★★ NJ, 2012-05-31 01:35 (5128 d 03:28 ago) Posting: # 8638 Views: 19,691 |
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Hi all, Why are there 2 different salts of D and L amphetamine in Adderall? D is more potent than L but what is the rationale for the two different salts? The only thing I can think of is to play around with solubility and the absorption rates. Thanks John |
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Helmut ★★★   Vienna, Austria, 2012-05-31 03:38 (5128 d 01:26 ago) @ jag009 Posting: # 8639 Views: 17,459 |
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Dear John! ❝ Why are there 2 different salts of D and L amphetamine in Adderall? Neither 2 nor 4 but 3 (sulfate, saccharate, aspartate):
❝ D is more potent than L … In most patients. Some showed better response to this weird mixture.* ❝ … but what is the rationale for the two different salts? Good question. ❝ The only thing I can think of is to play around with solubility and the absorption rates. Hhm. Amphetamine is highly soluble (BCS III, cLogP 1.285, logP 1.680) and almost completely absorbed. The anions are irrelevant. At least the price of d-amphetamine sulfate is astronomical. Maybe other salts are cheaper? 
— Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2012-05-31 20:02 (5127 d 09:01 ago) @ Helmut Posting: # 8646 Views: 17,381 |
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Thanks guys, Another question. When you do potency on this product (adderall XR), do you have to perform potency testing on the D and L separately (since it's 3:1 ratio) when compare between a test and reference? You know, the 5% rule... Thanks John |
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Helmut ★★★ Vienna, Austria, 2012-05-31 20:11 (5127 d 08:52 ago) @ jag009 Posting: # 8647 Views: 17,381 |
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Dear John! ❝ When you do potency on this product (adderall XR), do you have to perform potency testing on the D and L separately (since it's 3:1 ratio) when compare between a test and reference? You know, the 5% rule... Yep. Your product may be different in isomeric composition. Three years ago we found in Dexedrine [sic] ~4% l-amphetamine and in the test product (likely another supplier of the API) only 0.6%… — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2014-02-28 18:00 (4489 d 10:03 ago) @ Helmut Posting: # 12530 Views: 16,308 |
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Hi Helmut, old topic... ❝ Hhm. Amphetamine is highly soluble (BCS III, cLogP 1.285, logP 1.680) and almost completely absorbed. The anions are irrelevant. At least the price of d-amphetamine sulfate is astronomical. Maybe other salts are cheaper? Any idea where I can find info about amphetamine being BCS III? Thanks John |
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Helmut ★★★ Vienna, Austria, 2014-02-28 18:12 (4489 d 09:51 ago) @ jag009 Posting: # 12531 Views: 16,598 |
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Hi John, ❝ Any idea where I can find info about amphetamine being BCS III? I got the quoted values from TSRL’s BCS-Resources. Click “Access BCS Classification System Now“ (the direkt link changes almost monthly…). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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AngusMcLean ★★ USA, 2014-02-28 19:29 (4489 d 08:34 ago) @ jag009 Posting: # 12534 Views: 16,298 |
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The salts are very soluble, but the free base is an oil and is of course not as soluble. I think a salt of amphetamine is Class 1 BCS, highly soluble and highly permeable, since it is completely absorbed. ANGUS |
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Dr_Dan ★★ Germany, 2012-05-31 12:12 (5127 d 16:51 ago) @ jag009 Posting: # 8641 Views: 17,394 |
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Hi John The rationale for different salts is in most cases patent circumvention strategies, but I do not know if this is the case here. Kind regards Dan — Kind regards and have a nice day Dr_Dan |
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AngusMcLean ★★ USA, 2014-02-28 19:18 (4489 d 08:45 ago) @ jag009 Posting: # 12532 Views: 16,419 |
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The reason of formulating Adderall with mixed salts originally was to discourage generic companies from copying the product. The isomers nowadays are regarded as equipotent. I think it was originally for obesity. Angus |
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AngusMcLean ★★ USA, 2014-02-28 19:24 (4489 d 08:39 ago) @ jag009 Posting: # 12533 Views: 16,213 |
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There is no scientific rationale; I am aware of one company that tested the salts against each other and they were BE. |
Ing. Helmut Schütz