Bioequivalence and Bioavailability Forum

Today we got scientific advice
And our development got a little spice
We asked to do scaled bioequivalence
for a tablet against malignant flatulence
"We are no fools
We know the holy rules
So you can't use PROC MIXED
Cause the divine PK-group wants all factors fixed
And if you turn out to show supra-bioequivalence
Then you must suffer the ugly consequence
Low bioavailability will not escape our detection
- Your product will face rejection
Otherwise we'd all be walking around in a toxic haze
And the world would be a very smelly place."
So now unscaled bioequivalence is all we dare
And in the future we'll all be breathing fresh air.