practical
☆    

India,
2012-03-08 18:31
(5219 d 21:25 ago)

Posting: # 8238
Views: 3,945
 

 internal standard variation [Bioanalytics]

Hi to all

I have just a little query.
in am batch my IS variations is from 30% to 230% inspite of that all my QC & CC samples are passing.
so it has any impact on batch acceptance or not

thanks
Ohlbe
★★★

France,
2012-03-08 19:11
(5219 d 20:44 ago)

@ practical
Posting: # 8239
Views: 3,402
 

 internal standard variation

Dear practical,

Some reading material to explain why it is difficult to answer this question without seeing the data

Internal standard response variations during incurred sample analysis by LC–MS/MS: Case by case trouble-shooting
Aimin Tan, Saleh Hussain, Adrien Musuku, Robert Massé
Journal of Chromatography B, 877 (2009) 3201–3209

Regards
Ohlbe

Regards
Ohlbe
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