practical
☆    

India,
2012-03-08 18:31
(4831 d 16:04 ago)

Posting: # 8238
Views: 3,224
 

 internal standard variation [Bioanalytics]

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Hi to all

I have just a little query.
in am batch my IS variations is from 30% to 230% inspite of that all my QC & CC samples are passing.
so it has any impact on batch acceptance or not

thanks
 
Ohlbe
★★★

France,
2012-03-08 19:11
(4831 d 15:23 ago)

@ practical
Posting: # 8239
Views: 2,809
 

 internal standard variation

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Dear practical,

Some reading material to explain why it is difficult to answer this question without seeing the data

Internal standard response variations during incurred sample analysis by LC–MS/MS: Case by case trouble-shooting
Aimin Tan, Saleh Hussain, Adrien Musuku, Robert Massé
Journal of Chromatography B, 877 (2009) 3201–3209

Regards
Ohlbe
—
Regards
Ohlbe
 
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