Log in
Register|
auditor ★ India, 2011-08-11 17:24 (5046 d 12:56 ago) Posting: # 7279 Views: 4,143 |
|
|
Dear All, kindly advice probeble reason for below mentioned incident: in one of the my study the ISR meet the acceptance criteia about 60% and the whatever sample are not metting the acceptance are failing at negetive side (i.e the % diffrence is -25%, -30% etc). in this case i jsut want to know due to which reason the ISR samples are failing in negative side only. the samples which are meet the acceptance are also passing with the negative diffrence. I am suspecting this may happen due to matrix effect whcih may arrives after some time. kindly advice, is this cause for failing my ISR or any other reason is there.  Regards Auditor |
|
ElMaestro ★★★ Denmark, 2011-08-11 18:05 (5046 d 12:14 ago) @ auditor Posting: # 7280 Views: 3,499 |
|
|
Hi auditor, can you explain your situation with other and more words? It would be helpful for my understanding. And what exactly is your IS acceptance criterion? Many thanks. |
|
Helmut ★★★   Vienna, Austria, 2011-08-11 23:41 (5046 d 06:39 ago) @ auditor Posting: # 7281 Views: 3,509 |
|
|
Dear Auditor, please (again and again): Read and follow this post. You might have noticed that you got very few replies to your previous posts. One reason might be your sloppy spelling. If you want to be taken seriously try to invest some more time in formulating your questions in a way which is more easy to comprehend. THX. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
|
moblak ☆ 2011-08-22 14:57 (5035 d 15:22 ago) @ auditor Posting: # 7284 Views: 3,292 |
|
|
Hi Auditor, ❝ in one of the my study the ISR meet the acceptance criteia about 60% and the whatever sample are not metting the acceptance are failing at negetive side (i.e the % diffrence is -25%, -30% etc). One of the reasons for the negative ISR difference could be that your analyte is not stable in biol. matrix due to degradation, hydrolysis, formation of metabolites such as lactones ... Of course....taking into account that you are comparing ISR result to the original one: %diff=100*(ISR-Orig)/Orig or %diff=200*(ISR-Orig)/(ISR+Orig) Regards moblak |
Ing. Helmut Schütz