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baxivishal ☆ 2009-07-06 17:49 (6200 d 09:09 ago) Posting: # 3930 Views: 4,448 |
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Dear all Since we are in process of conducting leflunomide study i would like to know whether leflunomide tablets are available in extended release. Regards Vishal baxi |
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Helmut ★★★   Vienna, Austria, 2009-07-06 18:35 (6200 d 08:22 ago) @ baxivishal Posting: # 3931 Views: 3,596 |
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Dear Vishal! ❝ [...] whether leflunomide tablets are available in extended release. I don't think so. Note: if you want to submit to the FDA, only the metabolite A77 1726 should be measured. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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drcampos ★ Brazil, 2009-07-06 20:41 (6200 d 06:16 ago) @ baxivishal Posting: # 3933 Views: 3,875 |
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Dear Vishal, Leflunomide presents a half life of 11 days. Due to this long half life a modified release formulation is not necessary. regards, Daniel Rossi de Campos Brazil |
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Helmut ★★★ Vienna, Austria, 2009-07-06 20:51 (6200 d 06:06 ago) @ drcampos Posting: # 3934 Views: 3,587 |
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Dear Daniel! ❝ [...] Due this long half life a modified release formulation is not necessary. Exactly. But not everything in the world of big pharma is driven by science.  I once came across a drug, where the innovator got his first market authorization with a modified release formulation despite a half-live of two days. Obviously this was just done to make the life of generic companies miserable (it’s much more difficult to demonstrate BE of an MR formulation).— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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drcampos ★ Brazil, 2009-07-07 21:45 (6199 d 05:13 ago) @ Helmut Posting: # 3943 Views: 3,548 |
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Dear Helmut, I really appreciate your comments. Thank you!  regards, Daniel Rossi de Campos Brazil |
Ing. Helmut Schütz