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Ramesh ☆ India, 2008-04-23 20:10 (6637 d 03:57 ago) Posting: # 1794 Views: 4,112 |
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Dear group members, This is regarding the preparation of the master stock. for exampler as per the method my nominal concentration of the master stock is 1000 mcg/ml. if i prepare the stock of concentration 1000.2mcg/ml, is it possible to adjust the stock concentration of the prepared stock to concentration as per the method. can i do this procedure if no please give me justification for the same. with regards,  -- Edit: I changed your user-name from 'bebac' - I don't consider this camouflage-business funny...  See the section about 'sockpuppets' in the Forum's policy; your new account is blocked. [Helmut]  |
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Helmut ★★★   Vienna, Austria, 2008-04-23 21:29 (6637 d 02:38 ago) @ Ramesh Posting: # 1795 Views: 3,436 |
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Dear Ramesh! ❝ for exampler as per the method my nominal concentration of the master ❝ stock is 1000 mcg/ml. If you don't have anything else in place - describing the allowed accuracy of the weighing procedure - the number 1000 would suggest anything between 999.5 to 1000.4 as acceptable (otherwise you probably should have used the value 1000.0). ❝ if i prepare the stock of concentration 1000.2mcg/ml, is it possible to ❝ adjust the stock concentration of the prepared stock to concentration as ❝ per the method. There's nothing to adjust for. Use the concentration 'as is'. If your LOQ in validation was (by the chance of an exact weighing) let's say 10 ng/ml; with the new stock solution it's 10.002 ng/mL. So what... ❝ can i do this procedure if no please give me justification for the same. Which procedure; justification for what? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz