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dixit ★ India, 2011-05-05 09:07 (5531 d 06:14 ago) Posting: # 6993 Views: 3,636 |
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Dear all, Can any one please guide me regarding the fixing of sampling time points in sparse sampling studies. If possible please provide me good literature on it. Regards, DIXIT. |
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Helmut ★★★   Vienna, Austria, 2011-05-05 16:33 (5530 d 22:48 ago) @ dixit Posting: # 6995 Views: 2,972 |
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Dear Dixit! Are you interested in planning a Population PK study? You have to have access to at least one 'rich' data set. Set up the full model, estimate its parameters and subsequently eliminate data points (=reduced data sets). Estimate parameters of the model for the reduced data sets and assess the outcome based on bias (deviation from full data set's) and CVs. Though there are some strategies available (keywords: D-optimal design, informative block randomized design), the process is iterative and time-consuming. The only 'easy' case is an infusion, one-compartment model: Two time points - end of infusion, tlast.  Some references: D-optimal design, informative block randomized design. Recommended introduction: Amit Roy and Ene I. Ette — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz