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Rahul ☆ India, 2010-12-09 12:53 (5674 d 15:07 ago) Posting: # 6281 Views: 4,737 |
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Do anyone have info on "Effect of food on clopidogrel bioavailability"? how does a high fat-high calorie breakfast affects the Cmax or AUC in BA/BE trial... — Thanks n regards, Rahul... |
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d_labes ★★★ Berlin, Germany, 2010-12-09 15:02 (5674 d 12:58 ago) @ Rahul Posting: # 6282 Views: 3,949 |
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Dear Rahul,  keywords "Food effect Clopidogrel" gives approximately 491.000 results(0.24 sec). Chance is great to find your information needed among first of them.— Regards, Detlew |
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Rahul ☆ India, 2010-12-10 06:05 (5673 d 21:55 ago) (edited on 2010-12-10 10:10) @ d_labes Posting: # 6286 Views: 3,908 |
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Dear Labes, actually am asking about the possibility of observed data vaiation from the literature as it is highly variable drug... Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe] — Thanks n regards, Rahul... |
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Dr_Dan ★★ Germany, 2010-12-10 13:56 (5673 d 14:04 ago) @ Rahul Posting: # 6288 Views: 3,934 |
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Dear Rahul Unchanged clopidogrel has no effect on platelet aggregation. It is converted mainly to the inactive metabolite and to a less degree to the active thiol metabolite. This active metabolite irreversibly inhibits platelet aggregation. No validated analytical method exists to measure concentrations of the active metabolite after a 75 mg single dose reliably. According to the SPC of Plavix clopidogrel can be given independently from food, since the efficacy is not affected. This information is also based on pharmacokinetic properties of the inactive metabolite only, which is bioequivalent under fed and fasted conditions. The bioavailability of unchanged clopidogrel is strongly increased by food. McEwen J, Strauch G, Perles P, Pritchard G, Moreland TE, Necciari J, Dickinson JP: Clopidogrel Bioavailability: Absence of influence of food or antiacids. Seminars in Thrombosis and Hemostasis. 1999;25(2):47-50 Nirogi RVS, Kandikere VN, Mudigonda K: Effect of food on Bioavailability of a single oral dose of clopidogrel in healthy male subjects. Arzneim.-Forsch./Drug Res. 2006;56(11):735-739 I hope this helps Kind regards Dan — Kind regards and have a nice day Dr_Dan |
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Rahul ☆ India, 2010-12-16 06:52 (5667 d 21:08 ago) (edited on 2010-12-16 11:11) @ Dr_Dan Posting: # 6311 Views: 3,824 |
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Dear Dr. Dan, thanxs for ur input... Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Jaime] — Thanks n regards, Rahul... |
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Jaime_R ★★ Barcelona, 2010-12-16 12:24 (5667 d 15:36 ago) @ Rahul Posting: # 6312 Views: 3,803 |
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Dear Rahul, with one exception we had to clean all your posts. Please do not full quote in the future (see here and there). On top of the message area it reads: Please! Avoid full quotes (TOFU) and delete non required quoted text! --> delete text completely (JavaScript) Never seen?! — Regards, Jaime |
Ing. Helmut Schütz