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Priyanka_S ☆ 2010-02-06 07:53 (5979 d 06:34 ago) Posting: # 4720 Views: 3,684 |
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Dear Helmut, Generally we are considering study design as open label, balanced, randomized, two sequence, two period, two treatment, single dose crossover study. Is it necessary to keep "balanced" in the study design because we are considering unequal sequences also for statistical analysis. Edit. Subject line changed. [Helmut] — Best Regards Priyanka S |
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Helmut ★★★   Vienna, Austria, 2010-02-06 13:38 (5979 d 00:48 ago) @ Priyanka_S Posting: # 4722 Views: 3,013 |
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Dear Priyanka! ❝ Dear Helmut, ^^^^^^Not interested in the opinion of other forum members? ❝ Generally we are considering study design as […] balanced […] study. ❝ ❝ Is it necessary to keep "balanced" in the study design because we are considering unequal sequences also for statistical analysis. You should plan for a balanced design. If the study becomes imbalanced due to drop-outs, the statistical analysis will account for that (adjusted means instead of geometric means, or in SAS' terminology: least squares means). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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bharat ☆ India, 2010-02-17 12:20 (5968 d 02:06 ago) @ Priyanka_S Posting: # 4778 Views: 2,882 |
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Dear Priyanka Study should be design 'Balanced'. If due to droupout or withdrawal it is not balanced no issue at all. Regards Bharat Narnavar Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe] |
Ing. Helmut Schütz