maverick
☆    

India,
2009-10-06 15:04
(6109 d 15:14 ago)

Posting: # 4300
Views: 4,972
 

 Levomepromazine [Design Issues]

Post reply
Dear All,
can anyone pass on the statistical details viz %CV, 90% CI for any pilot Pharmacokinetic BE study conducted on Levomepromazine maleate 25 mg tablets under fasted conditions?

Best Regards,
Maverick

Edit: Category changed. [Helmut]
 
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2009-10-06 18:52
(6109 d 11:26 ago)

@ maverick
Posting: # 4305
Views: 4,331
 

 Levomepromazine

Post reply
Hi Maverick!

Sorry no 25 mg, but one example (100 mg, n=12) may serve as a starting point:

Bagli et al.
Bioequivalence and absolute bioavailability of oblong and coated levomepromazine tablets in CYP2D6 phenotyped subjects
Int J Clin Pharmacol Ther 33/12, 646-652 (1995)

From the reported CIs I calculate a CVintra of ~25% for AUCinf and ~28% for Cmax.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
 
UA Flag
Activity
 Admin contact
23,655 posts in 4,993 threads, 1,570 registered users;
344 visitors (0 registered, 344 guests [including 13 identified bots]).
Forum time: 06:18 CEST (Europe/Vienna)

Most scientists today are devoid of ideas, full of fear, intent on
producing some paltry result so that they can add to the flood
of inane papers that now constitutes “scientific progress”
in many areas.    Paul Feyerabend

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5