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santosh.awale ☆ Mumbai, 2008-12-29 07:31 (6391 d 06:54 ago) Posting: # 2983 Views: 4,059 |
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Hi to all, we have one project for iodine solution skin irritation test in human, in that positive control is 20% Sodium Lauryl Sulfate (SLS) taken as standard, we did practically in laboratory by using 20% SLS but we don't get irritation, so if you know other positive control substance in skin irritation test please suggest me.. Thank You, Regards.. Santosh A. |
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santosh.awale ☆ Mumbai, 2009-01-20 12:12 (6369 d 02:13 ago) @ santosh.awale Posting: # 3069 Views: 3,707 |
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hi to all, ❝ we have one project for iodine solution skin irritation test in human, in that positive control is 20% Sodium Lauryl Sulfate (SLS) taken as standard, we did practically in laboratory by using 20% SLS but we don't get irritation i get some positive control substance which can used in skin irritation test... 20% Sodium Lauryl Sulfate (99% purity), 20% Sodium Dodecyl Sulfate, 0.1 to 0.5 1-chloro, 2,4 dinitrobenzene (DNCB), now my one problem is solved but for protocol design of skin irritation test i follow "Guidance for Industry Skin Irritation and Sensitization Testing of Generic Transdermal Drug products" but this is for the patches but our test product is in solution form, can i follow this guidelines or any other guidelines for solution to test skin irritation. Regards, Santosh A. -- Edit: Guidance linked. Doesn't the document 'speak' of 'e.g., sodium lauryl sulfate'? [Helmut] |
Ing. Helmut Schütz