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santosh.awale ☆ Mumbai, 2008-12-06 13:48 (6406 d 10:45 ago) Posting: # 2888 Views: 4,629 |
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Hi to all, when tel is equal or more than 24 hours, then we will go for Truncated, but what is limit for tel for Truncated design? when we go for parallel design (what is limit for tel for parallel design)? give your comments........ thank you and regards, Santosh A. |
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Helmut ★★★   Vienna, Austria, 2008-12-06 17:18 (6406 d 07:15 ago) @ santosh.awale Posting: # 2890 Views: 3,930 |
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Dear Santosh! ❝ when tel is equal or more than 24 hours, then we will go for ❝ Truncated, but what is limit for tel for Truncated design? when ❝ we go for parallel design (what is limit for tel for parallel ❝ design)? There's no agreement, but Canada suggested 24 hours in 2005. The European Draft Guideline from 2008 suggested no sampling beyond 72 hours for all IR formulations irrespective of the half-life. ❝ when we go for parallel design (what is limit for tel for ❝ parallel design)? It's up to you. ± points you should consider: - Power (for a given sample size) in a parallel design is lower than in a cross-over + Less chance for drop-outs in a long wash-out — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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santosh.awale ☆ Mumbai, 2008-12-08 08:02 (6404 d 16:31 ago) @ Helmut Posting: # 2892 Views: 3,747 |
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Dear Helmut sir, thank you for giving suggesion and link. thanks a lot, with regards, Santosh A. |
Ing. Helmut Schütz