atak
●    

2008-08-05 15:58
(6533 d 09:41 ago)

Posting: # 2150
Views: 3,433
 

 AUC%extrapolated [Design Issues]

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Dear friends,
In case of AUC%extrapolated more than 20% in some subject, how to proceed for the calculation of the AUCinf? why? Plz tell me in detail.
Thanks,
Atak
 
JPL
☆    

Vienna,
2008-08-06 12:53
(6532 d 12:46 ago)

@ atak
Posting: # 2153
Views: 2,639
 

 AUC%extrapolated

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Dear Atak,

there is a rule stating to exclude AUC0-Inf if the extrapolated area is more than 20% of AUC0-tlast. If so, this indicates that your observational period was not long enough to turn into the terminal phase or that the data are implausible for some reason.
However, the 20% are only some arbitrary value and if you do not state this rule before analysis, you will get into trouble.
Regards,
JPL
 
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