Bioequivalence and Bioavailability Forum • PPI Washout

Jay
☆

India,
2016-05-11 10:57
(3702 d 06:36 ago)

Posting: # 16290
Views: 6,895

PPI Washout [Design Issues]

Dear All,

The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable? As PPI influence the acid level by inhibiting the acid release from parietal cells, so would this effect the absorption of the drug if washout is kept 1-2 days.

Regards,
Jay

Edit: Category changed; see also this post #1. [Helmut]

luvblooms
★★

India,
2016-05-11 14:06
(3702 d 03:27 ago)

@ Jay
Posting: # 16292
Views: 5,484

PPI Washout

Post reply

Dear Jay,

❝ The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable?

This is elimination half life we are talking about not the half life of drug action. ;-)

❝ As PPI influence the acid level by inhibiting the acid release from parietal cells, so would this effect the absorption of the drug if washout is kept 1-2 days.

To understand this you need to look for few things as

Exact mechanism of action of PPIs
Regeneration rate of Proton pumps
At a given point of time how many proton pumps are active/regenerating/nascent phase
Time for which pH is above 4.5 (for few PPIs it has been more than 18 hrs)

Look for the points I shared and then you will be able to understand why washout of 1-2 day is a really bad idea.

Hope this will help.

—
~A happy Soul~

jag009 ★★★ NJ, 2016-05-16 00:19 (3697 d 17:14 ago) @ luvblooms Posting: # 16311 Views: 5,333	PPI Washout Post reply
	❝ Dear Jay, ❝ ❝ ❝ The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable? ❝ ❝ This is elimination half life we are talking about not the half life of drug action. You are using mean? Better look at the SD and ranges. John