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eswar ● 2008-01-28 12:30 (6722 d 15:04 ago) Posting: # 1564 Views: 4,672 |
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hi this is eswar, working as a statistician in a CRO. I would like to go for analysis of one steady state study. please provide to me about study state study, what are the parameters used in analysis of steady state studies, and how they calculate. please provide to me one example on steady state studies. thanks & regards eswar |
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Jaime_R ★★ Barcelona, 2008-01-28 13:41 (6722 d 13:53 ago) @ eswar Posting: # 1566 Views: 4,048 |
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Dear Eswar! ❝ I would like to go for analysis of one steady state study. please provide to ❝ me about study state study,... Search the forum.  For basics see this post, for references that one. ❝ ... what are the parameters used in analysis of steady state studies Main parameters are AUC0-tau (or if diurnal variation is possible AUC0-24h), Css,max, PTF ([Css,max-Css,min]/Css,av, where Css,av=AUC0-tau/tau),... See also the guideline page. ❝ ... and how they calculate. By noncompartmental analysis (NCA). ❝ please provide to me one example on steady state studies. Please do your homework first; sorry, but this would go beyond the limits of a single post. We are posting here in our leisure time - maybe one of Helmut's lectures would help (look for the 'Istanbul' series). — Regards, Jaime |
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opinion@experience ● 2008-07-16 14:20 (6552 d 14:14 ago) @ Jaime_R Posting: # 2046 Views: 3,793 |
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You may also need to include Cssmin and Percent Swing. |
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Nirali ★ India, 2008-02-15 08:29 (6704 d 19:05 ago) @ eswar Posting: # 1613 Views: 3,857 |
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Dear Eswar, Canadian guideline [Conduct & Analysis of BA and BE studies-Part B: Oral Modified Release Formulations] has best examples for steady state analysis. May I know which software are you using for Bioequivalence analysis? Thanks & Regards, Nirali |
Ing. Helmut Schütz