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SKR ☆ 2007-12-01 14:21 (6781 d 15:28 ago) Posting: # 1349 Views: 5,706 |
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Dear HS, I would appreciate ur help in this regard. Here is a question regarding replicate design. As there are some logistic reasons, the replicate study has been conducted in two groups. I used the SAS code given in "FDA guidance Statistical Approaches to Establishing Bioequivalence" for ANOVA and CI calculation. How to test the group effect? which factors the ANOVA model should include? Thanks in advance  |
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Helmut ★★★   Vienna, Austria, 2007-12-02 13:43 (6780 d 16:05 ago) @ SKR Posting: # 1350 Views: 3,907 |
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Dear SKR! ❝ […] How to test the group effect? which factors the ANOVA model should include? IMHO you should add a Group and a Treatment by Group interaction term as fixed effects. See also this post. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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d_labes ★★★ Berlin, Germany, 2008-01-23 16:52 (6728 d 12:57 ago) @ Helmut Posting: # 1546 Views: 3,581 |
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Dear HS, ❝ IMHO you should add a Group and a Treatment by Group interaction term as fixed effects. See also this post. in the linked post you do not recommend a group by period interaction. How can we then interpret the paragraph VII A "Studies in multiple groups" in the FDA guidance "... In particular, the model should reflect the fact that the periods for the first group are different from the periods for the second group. ...". To my understanding this calls for group by period interaction.? Regards, D_Labes — Regards, Detlew |
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Helmut ★★★ Vienna, Austria, 2008-01-23 18:02 (6728 d 11:47 ago) @ d_labes Posting: # 1549 Views: 3,767 |
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Dear D_Labes! ❝ ❝ […] See also this post. ❝ in the linked post you do not recommend a group by period interaction. ❝ How can we then interpret the paragraph VII A "Studies in multiple groups" in the FDA guidance ❝ "… In particular, the model should reflect the fact that the periods for the first group are different from the periods for the second group…". ❝ To my understanding this calls for group by period interaction.? Please see also this post. But of course, this is just my personal opinion… — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz