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john john ☆ Spain, 2014-12-02 10:19 (4218 d 16:07 ago) Posting: # 13963 Views: 6,337 |
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Hi For a bioequivalence study of two drugs with 34 volunteers, how should be a block randomization? What size should be the blocks? |
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Dr_Dan ★★ Germany, 2014-12-02 10:42 (4218 d 15:44 ago) @ john john Posting: # 13965 Views: 5,266 |
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Dear John I am not an expert in randomization, however, 34:2=17. You can not devide 17 into equal blocks. So you will have only two blocks, right? Kind regards Dr_Dan — Kind regards and have a nice day Dr_Dan |
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Helmut ★★★   Vienna, Austria, 2014-12-02 13:19 (4218 d 13:07 ago) @ john john Posting: # 13967 Views: 5,255 |
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Hi John II ❝ For a bioequivalence study of two drugs with 34 volunteers, how should be a block randomization? What size should be the blocks? What’s your rationale? Are you aiming at stratification (let’s say for sex)? See this lengthy thread about blocks. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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john john ☆ Spain, 2014-12-02 13:59 (4218 d 12:27 ago) @ Helmut Posting: # 13968 Views: 5,216 |
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Hi Helmut I’m not going to do stratification, but I think we have to use blocks of different sizes randomly selected, is that correct? Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut] |
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Helmut ★★★ Vienna, Austria, 2014-12-03 03:00 (4217 d 23:26 ago) @ john john Posting: # 13969 Views: 5,229 |
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Hi John II, ❝ I’m not going to do stratification, but I think we have to use blocks of different sizes randomly selected, is that correct? Did you read the linked thread? Do whatever you like. BE studies are generally open-label. What do you hope to gain by different block sizes – except satisfying blockheaded inspectors? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz