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AngusMcLean ★★ USA, 2013-02-16 06:27 (4876 d 07:41 ago) Posting: # 10038 Views: 6,528 |
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If we take the example of a cross over study the standard balanced design has 2 periods, 2 sequences (A-B and B-A) with two treatments(test v reference) and an even number of subjects with a wash out between treatments. Now if there is only one sequence used for the crossover what is the best way to treat the data from the point of view of confidence intervals approach. I realize this is a non standard approach. i have EquivTest and WinNonlin. Angus |
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yicaoting ★ NanKing, China, 2013-02-16 10:27 (4876 d 03:41 ago) @ AngusMcLean Posting: # 10039 Views: 5,461 |
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It becomes a standard paired design study. You can do it with EquivTest. Edit: Please follow the Forum’s Policy. [Helmut] |
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AngusMcLean ★★ USA, 2013-02-16 16:00 (4875 d 22:07 ago) @ yicaoting Posting: # 10044 Views: 5,401 |
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❝ It becomes a standard paired design study. ❝ You can do it with EquivTest. Thank you! I will use EquivTest |
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Helmut ★★★   Vienna, Austria, 2013-02-16 15:30 (4875 d 22:37 ago) @ AngusMcLean Posting: # 10042 Views: 5,503 |
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Hi Angus, in both (classical) WinNonlin and Phoenix start with Parallel/Other, drag/map Subject to Classification Variables, and specify the model as Subject+Formulation.WinNonlin ![[image]](img/uploaded/image146.png) ![[image]](img/uploaded/image147.png) Phoenix ![[image]](img/uploaded/image148.png) ![[image]](img/uploaded/image149.png) — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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walsu ☆ Korea, 2014-04-01 16:16 (4466 d 22:51 ago) @ Helmut Posting: # 12749 Views: 4,725 |
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I have some questions. In this design (paired design), is it possible to calculate intrasubject CV? What is the exact name of this design? 'One sequence crossover' or 'standard paired study'? If I run crossover mode in Phoenix with dummy suquence(seq=1), is it same with parallel/other mode in Phoenix? Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe] |
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Helmut ★★★ Vienna, Austria, 2014-04-01 19:53 (4466 d 19:14 ago) @ walsu Posting: # 12751 Views: 4,646 |
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Hi Walsu, ❝ In this design (paired design), is it possible to calculate intrasubject CV? Sure. Calculate it by the usual formula from the residual variance (in Phoenix: Output Data > Final Variance Parameters).❝ What is the exact name of this design? 'One sequence crossover' or 'standard paired study'? It’s a paired design. There are no “sequences” – one treatment follows the other. No randomization, fixed order. Note that in this model we assume no (or better: equal) period effects. Might sound strange first, but we regularly apply such a model in the evaluation of PK-linearity (AUC0–τ in steady state vs. AUC0–∞ after a single dose). Steady state follows single dose, right? ❝ If I run crossover mode in Phoenix with dummy suquence(seq=1), is it same with parallel/other mode in Phoenix? No idea. Why didn’t you try it yourself first? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz