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swapnil.kuche ★ 2011-08-04 11:22 (5444 d 00:31 ago) Posting: # 7257 Views: 4,161 |
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Dear All, Please comment on following queries regarding IVIVC 1) Is it required to conduct IVIVC for all modified relese drug product if drug product complies with BCS requirement for IVIVC? Please explain in which scenario we have to condduct IVIVC? 2) What is requirement of slow, medium and fast release formulation in IVIVC? Which type of corelation is this? 3) Please explian me in which type of formulation following metrices will be evaluated and why? i) Cmax/AUC ii)MRT iii)POT-25, T75% iv) HVD, POT-50 v)%PTF vi)%Swing vii)%AUCF viii) T75% ix)Partial AUC Regards, Swapnil D. Kuche |
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swapnil.kuche ★ 2011-08-05 12:41 (5442 d 23:11 ago) @ swapnil.kuche Posting: # 7265 Views: 3,475 |
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Dear All, Please comment on my above query at earliset if possible Regards, Swapnil D. Kuche |
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Helmut ★★★   Vienna, Austria, 2011-08-05 12:51 (5442 d 23:01 ago) @ swapnil.kuche Posting: # 7266 Views: 3,469 |
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Dear Swapnil! ❝ Please comment on my above query at earliset if possible Please follow the Forum’s Policy! We are posting here in our freetime, and if someone asks me to answer ‘at earliest as possible’, I’m definitely not in the mood for doing so at all.  — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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swapnil.kuche ★ 2011-08-05 13:01 (5442 d 22:52 ago) @ Helmut Posting: # 7267 Views: 3,453 |
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Dear HS Sincere apologise if anyone find my language rude. Anyways i will take care for the same in future. By the way ❝ at earliest as possible’ Actually it is 'at earliest if possible’ Regards, Swapnil |
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yjlee168 ★★★  Kaohsiung, Taiwan, 2011-08-05 16:35 (5442 d 19:17 ago) @ swapnil.kuche Posting: # 7270 Views: 3,458 |
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Dear Swapnil, There have been a lots of posts or pointers discussed in this Forum about your questions. Please use "Search" function on the upper right corner with key words such as ivivc, in-vitro in-vivo, etc.. You will find the answers from searched results, particularly this post by Helmut. That's what I do. Also, you may need a textbook about ivivc, e.g. this one. You also can Google it. Hope this can help. — All the best, -- Yung-jin Lee bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee Kaohsiung, Taiwan https://www.pkpd168.com/bear Download link (updated) -> here |
Ing. Helmut Schütz