jag009
★★★

NJ,
2015-11-16 17:28
(3878 d 03:02 ago)

Posting: # 15641
Views: 4,235
 

 FDA BE: Truncate AUC for long half-life drug [Regulatives / Guidelines]

Post reply
Hi all,

Truncate AUC can be used for a drug with long half-life. Question, is there a limitation as to how long? What if the molecule of interest has a half-life of 15-20 days? Still applicable?

Thanks
John
 
d_labes
★★★

Berlin, Germany,
2015-11-16 17:51
(3878 d 02:38 ago)

@ jag009
Posting: # 15642
Views: 3,273
 

 FDA BE: Truncate AUC for long half-life drug

Post reply
Dear John!

Forgotten your own question on the same subject :-D? And Helmut's answer? Here is it.

Ok it's from 2012. But AFAIK there is no new information on this subject meanwhile. Beside the fact that for highly variable drugs truncation shouldn't be used. See f.i. this thread.
—
Regards,

Detlew
 
UA Flag
Activity
 Admin contact
23,656 posts in 4,994 threads, 1,570 registered users;
281 visitors (0 registered, 281 guests [including 27 identified bots]).
Forum time: 21:30 CEST (Europe/Vienna)

Most scientists today are devoid of ideas, full of fear, intent on
producing some paltry result so that they can add to the flood
of inane papers that now constitutes “scientific progress”
in many areas.    Paul Feyerabend

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5